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Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Xu, Changzhi
;
Zhang, Lanlan
;
He, Huimin
;
Liu, Xiaoyi
;
Pei, Xinxin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
sheep tail fat
non-small-cell lung cancer
heptadecanoic acid
antiproliferative effect
Akt
S6K signaling pathway
The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2021, 卷号: 20, 期号: 11, 页码: 2198-2206
作者:
Jiang, Yuchen
;
Peng, Xia
;
Ji, Yinchun
;
Dai, Yang
;
Fang, Yanfen
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/16
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:
Han, Xu
;
Song, Ning
;
Saidahmatov, Abdusaid
;
Wang, Peipei
;
Wang, Yong
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  |  
浏览/下载:16/0
  |  
提交时间:2021/12/16
In vitro studies of deferasirox derivatives as potential organelle-targeting traceable anti-cancer therapeutics
期刊论文
CHEMICAL COMMUNICATIONS, 2021, 页码: 4
作者:
Steinbrueck, Axel
;
Sedgwick, Adam C.
;
Han, Hai-Hao
;
Zhao, Michael Y.
;
Sen, Sajal
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  |  
浏览/下载:39/0
  |  
提交时间:2021/06/11
Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
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  |  
浏览/下载:42/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
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  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 11
作者:
Qiu, Xiaqiu
;
Li, Yuanqing
;
Yu, Bin
;
Ren, Jie
;
Huang, Huidan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
CDK9
Antitumor
PROTAC
AML
Degrader
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
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