Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo

doi:10.3389/fphar.2022.917513

	Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo
	Xu, Changzhi 4; Zhang, Lanlan 4; He, Huimin 4; Liu, Xiaoyi 4; Pei, Xinxin 4; Ma, Tengfei 2,3; Ma, Bingbing 2,3; Lin, Wenchu 1; Zhang, Buchang 4
刊名	FRONTIERS IN PHARMACOLOGY
	2022-08-11
卷号	13
关键词	sheep tail fat non-small-cell lung cancer heptadecanoic acid antiproliferative effect Akt S6K signaling pathway
DOI	10.3389/fphar.2022.917513
通讯作者	Lin, Wenchu(wenchu@hmfl.ac.cn) ; Zhang, Buchang(zhbc@ahu.edu.cn)
英文摘要	Increasing evidence suggests that numerous edible oils may function as adjuvant dietary therapies to treat cancer. We previously reported that the odd-chain saturated fatty acid (OCSFA), heptadecanoic acid (C17:0), profoundly inhibits non-small-cell lung cancer (NSCLC) cell proliferation. However, the antitumor potential of edible lipids rich in C17:0 remains unclear. Here, we determined that sheep tail fat (STF) is a dietary lipid rich in C17:0 and exhibited the greatest inhibitory effect against three NSCLC cell lines (A549, PC-9, and PC-9/GR) among common dietary lipids. Cell migration experiments demonstrated that STF could significantly inhibit the wound healing capacity of three NSCLC cell lines by promoting the generation of reactive oxygen species (ROS) and subsequent cell death. Mechanistic studies showed that STF suppressed NSCLC cell growth by downregulating the Akt/S6K signaling pathway. Furthermore, administration of STF reduced tumor growth, weight, and expression of the proliferative marker Ki-67 in nude mice bearing A549 xenografts. Collectively, our data show that STF has antitumor activity against NSCLC, implying that dietary intake of C17:0-rich STF may be a potential adjuvant therapy for NSCLC.
资助项目	Science and Technology Major Project of Anhui Province, China ; innovation and entrepreneurship project of high-level scientific and technological talent teams in Anhui Province[202003a06020026]
WOS关键词	CORONARY-HEART-DISEASE ; DIETARY ; ACID ; RISK ; ASSOCIATION ; MECHANISMS ; RESISTANCE ; ANTITUMOR ; HEALTH ; LIFE
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000844661100001
资助机构	Science and Technology Major Project of Anhui Province, China ; innovation and entrepreneurship project of high-level scientific and technological talent teams in Anhui Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/132047]
专题	中国科学院合肥物质科学研究院
通讯作者	Lin, Wenchu; Zhang, Buchang
作者单位	1.Chinese Acad Sci, High Magnet Field Lab, Hefei, Anhui, Peoples R China 2.Fuyang Tianxiang Food Technol Co Ltd, Fuyang, Anhui, Peoples R China 3.Anhui Tianxiang Grain & Oil Food Co Ltd, Fuyang, Anhui, Peoples R China 4.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Xu, Changzhi,Zhang, Lanlan,He, Huimin,et al. Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo[J]. FRONTIERS IN PHARMACOLOGY,2022,13.
APA	Xu, Changzhi.,Zhang, Lanlan.,He, Huimin.,Liu, Xiaoyi.,Pei, Xinxin.,...&Zhang, Buchang.(2022).Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo.FRONTIERS IN PHARMACOLOGY,13.
MLA	Xu, Changzhi,et al."Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo".FRONTIERS IN PHARMACOLOGY 13(2022).