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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin
期刊论文
MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 卷号: 30
作者:
Zhang, Lin
;
Li, Ling
;
Wang, Xia
;
Liu, Huimin
;
Zhang, Yibin
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  |  
浏览/下载:23/0
  |  
提交时间:2022/12/23
Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
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  |  
浏览/下载:18/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Evaluation of beamline subsystem performance during technical commissioning of an superconducting proton therapy facility
期刊论文
JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY, 2022
作者:
Zheng, Jinxing
;
Zeng, Xianhu
;
Wang, Cheng
;
Huang, Dixi
;
Cheng, Yiyue
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  |  
浏览/下载:47/0
  |  
提交时间:2022/03/21
Proton therapy
beamline
beam optics
technical commissioning
Identifying the Active Phenanthrene Degraders and Characterizing Their Metabolic Activities at the Single-Cell Level by the Combination of Magnetic-Nanoparticle-Mediated Isolation, Stable-Isotope Probing, and Raman-Activated Cell Sorting (MMI-SIP-RACS)
期刊论文
Environmental Science & Technology, 2022, 卷号: 56, 期号: 4, 页码: 2289-2299
作者:
J. B. Li
;
D. Y. Zhang
;
B. Li
;
C. L. Luo and G. Zhang
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  |  
浏览/下载:2/0
  |  
提交时间:2023/06/14
Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14822-14847
作者:
Wei, Dan
;
Wang, Hanlin
;
Zeng, Qinghe
;
Wang, Wenjing
;
Hao, Bingbing
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  |  
浏览/下载:30/0
  |  
提交时间:2021/12/16
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:
Yang, Xiangbo
;
Wang, Zhijia
;
Pei, Yuan
;
Song, Ning
;
Xu, Lei
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  |  
浏览/下载:38/0
  |  
提交时间:2021/08/17
SHP2 degradation
Proteolysis targeting chimera (PROTAC)
Thalidomide-based heterobifunctional molecules
E3 ubiquitin ligase
CRBN
Prototype development of the beam diagnostic system of a proton therapy facility based on a superconducting cyclotron
期刊论文
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2021, 卷号: 998, 页码: 6
作者:
Chen, Aote
;
Chen, Qushan
;
Liu, Xu
;
Zhou, Chong
;
Li, Dong
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  |  
浏览/下载:19/0
  |  
提交时间:2021/12/10
Proton therapy
Beam diagnostic system
Beam diagnostic detectors
Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 11
作者:
Qiu, Xiaqiu
;
Li, Yuanqing
;
Yu, Bin
;
Ren, Jie
;
Huang, Huidan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
CDK9
Antitumor
PROTAC
AML
Degrader
Nutrient depletion is the main limiting factor in the crude oil bioaugmentation process
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES, 2021, 卷号: 100, 页码: 317-327
作者:
Sun, Yanyu
;
Chen, Weiwei
;
Wang, Yibo
;
Guo, Jie
;
Zhang, Haikun
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  |  
浏览/下载:40/0
  |  
提交时间:2021/06/07
Crude oil bioaugmentation
Bacterial community dynamic shift
Enhanced green fluorescent protein
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