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浏览/检索结果: 共11条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序提交时间升序提交时间降序题名升序题名降序作者升序作者降序 Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207 作者:  Du, Daohai;  Xu, Dandan;  Zhu, Licheng;  Stazi, Giulia;  Zwergel, Clemens 收藏  |  浏览/下载：71/0  |  提交时间：2021/08/17 A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats 期刊论文 AMERICAN JOURNAL OF NEPHROLOGY, 2020, 卷号: 51, 期号: 1, 页码: 1-10 作者:  Li, Xin;  Wu, Ming;  Chen, Limin;  Lu, Junyan;  Li, Guo 收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 FTY720  Sphingosine-1-phosphate  Cordyceps sinensis  Autosomal dominant polycystic kidney disease  Inflammation   Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文 BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298 作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan 收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Arginine methylation  Virtual screening  Molecular docking  Molecular dynamics simulation   Identification of a novel selective small-molecule inhibitor of protein arginine methyltransferase 5 (PRMT5) by virtual screening, resynthesis and biological evaluations 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 9, 页码: 1476-1483 作者:  Zhu, Kongkai;  Jiang, Chengshi;  Tao, Hongrui;  Liu, Jingqiu;  Zhang, Hua 收藏  |  浏览/下载：59/0  |  提交时间：2019/01/08 PRMT5 inhibitor  Resynthesis  Virtual screening  Molecular docking  Molecular dynamics simulation   Discovery of potent DOT1L inhibitors by AlphaLISA based High Throughput Screening assay 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8, 页码: 1751-1758 作者:  Song, Yakai;  Li, Linjuan;  Chen, Yantao;  Liu, Jingqiu;  Xiao, Senhao 收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 DOT1L  MLL-rearranged leukemia  AlphaLISA  HTS  Novel inhibitors   developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors 期刊论文 actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 302 作者:  Zhu Maorong;  Du Daohai;  Hu Junchi;  Li Lianchun;  Liu Jingqiu 收藏  |  浏览/下载：59/0  |  提交时间：2020/07/01 PRC2  EZH2  EED  protein-protein interaction  fluorescence polarization  high-throughput screening  apomorphine hydrochloride  oxyphenbutazone  nifedipine  ergonovine maleate   Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer 期刊论文 CANCER CELL, 2016, 卷号: 30, 期号: 3, 页码: 474-484 作者:  Guo, Zhong-Qiang;  Zheng, Tong;  Chen, Baoen;  Luo, Cheng;  Ouyang, Sisheng 收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08 Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2016, 卷号: 56, 期号: 3, 页码: 527-534 作者:  Chen, Shijie;  Li, Linjuan;  Chen, Yantao;  Hu, Junchi;  Liu, Jingqiu 收藏  |  浏览/下载：19/0  |  提交时间：2019/01/08 Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 57, 期号: 22, 页码: 9512-9521 作者:  Kong, Xiangqian;  Chen, Limin;  Jiao, Lianying;  Jiang, Xiangrui;  Lian, Fulin 收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08 Identifying Novel Selective Non-Nucleoside DNA Methyltransferase 1 Inhibitors through Docking-Based Virtual Screening 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2014, 卷号: 57, 期号: 21, 页码: 9028-9041 作者:  Chen, Shijie;  Wang, Yulan;  Zhou, Wen;  Li, Shanshan;  Peng, Jianlong 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08