CORC

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CORC

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Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2 期刊论文
LEUKEMIA, 2022
作者:  Yang, Jing;  Weisberg, Ellen L.;  Qi, Shuang;  Ni, Wei;  Mei, Husheng
收藏  |  浏览/下载：73/0  |  提交时间：2022/02/14
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:  Du, Daohai;  Xu, Dandan;  Zhu, Licheng;  Stazi, Giulia;  Zwergel, Clemens
收藏  |  浏览/下载：71/0  |  提交时间：2021/08/17
SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways 期刊论文
CANCER CELL, 2020, 卷号: 38, 期号: 3, 页码: 350-+
作者:  Yuan, Huairui;  Han, Ying;  Wang, Xuege;  Li, Ni;  Liu, Qiuli
收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24
Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:  Zhou, Yan;  Du, Dao-Hai;  Wang, Jia;  Cai, Xiao-Qing;  Deng, Alicia X.
收藏  |  浏览/下载：101/0  |  提交时间：2020/07/01
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition (vol 0, pg 1, 2019) 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 2
作者:  Zhang, Kai-li;  Shen, Qian-qian;  Fang, Yan-feng;  Sun, Yi-ming;  Ding, Jian
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations 期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 1, 页码: 58-63
作者:  Zhu, Kongkai;  Du, Daohai;  Yang, Rui;  Tao, Hongrui;  Zhang, Hua
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01
PRC2 and EHMT1 regulate H3K27me2 and H3K27me3 establishment across the zygote genome 期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1
作者:  Meng Tie-Gang;  Zhou Qian;  Ma Xue-Shan;  Liu Xiao-Yu;  Meng Qing-Ren
收藏  |  浏览/下载：9/0  |  提交时间：2021/10/26
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:  Zhang, Kai-li;  Shen, Qian-qian;  Fang, Yan-fen;  Sun, Yi-ming;  Ding, Jian
收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01
Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:  Ye, Fei;  Huang, Jing;  Wang, Hongbo;  Luo, Cheng;  Zhao, Kehao
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:  Shi, Yi;  Ma, Hong-lei;  Zhuang, You-wen;  Wang, Xiao-xi;  Jiang, Yi
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01

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