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Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8194-8207
作者:
Du, Daohai
;
Xu, Dandan
;
Zhu, Licheng
;
Stazi, Giulia
;
Zwergel, Clemens
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/08/17
Silver nanoparticles (AgNPs) and AgNO3 perturb the speci fication of human hepatocyte-like cells and cardiomyocytes
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 卷号: 725, 页码: 1-10
作者:
Hu, Bowen
;
Yin, Nuoya
;
Yang, Renjun
;
Liang, Shengxian
;
Liang, Shaojun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/09/14
Human embryonic stem cells (hESCs)
Silver nanoparticles (AgNPs)
Developmental toxicity
Hepatocyte-like cells
Cardiomyocytes
Stem cell toxicology
Non-cytotoxic silver nanoparticle levels perturb human embryonic stem cell-dependent specification of the cranial placode in part via FGF signaling
期刊论文
JOURNAL OF HAZARDOUS MATERIALS, 2020, 卷号: 393, 页码: 1-9
作者:
Hu, Bowen
;
Yang, Renjun
;
Cheng, Zhanwen
;
Liang, Shaojun
;
Liang, Shengxian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/09/14
Silver nanoparticles (AgNPs)
Ectoderm
Developmental toxicity
Stem cell toxicology
Cranial placode
Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:
Zhou, Yan
;
Du, Dao-Hai
;
Wang, Jia
;
Cai, Xiao-Qing
;
Deng, Alicia X.
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  |  
浏览/下载:102/0
  |  
提交时间:2020/07/01
embryonic ectoderm development
Enhancer of zeste homolog 2
fluorescence polarization
high-throughput screening
homogenous time-resolved fluorescence
inhibitor
polycomb repressive complex 2
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 379, 页码: -
作者:
Liang, Shengxian
;
Liang, Shaojun
;
Yin, Nuoya
;
Hu, Bowen
;
Faiola, Francesco
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/09/10
BDE-47/209
TBBPA/S
TCBPA
Human embryonic stem cells
Developmental neural toxicity
DEP and DBP induce cytotoxicity in mouse embryonic stem cells and abnormally enhance neural ectoderm development
期刊论文
ENVIRONMENTAL POLLUTION, 2018, 卷号: 236, 页码: 21-32
作者:
Jiang, Guibin
;
Faiola, Francesco
;
Zhou, Qunfang
;
Yang, Renjun
;
Hu, Bowen
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/06/20
DEP
DBP
Embryonic stem cell
Developmental neural toxicity
Phthalate
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 302-310
作者:
Zhu, Mao-rong
;
Du, Dao-hai
;
Hu, Jun-chi
;
Li, Lian-chun
;
Liu, Jing-qiu
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  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 302
作者:
Zhu Maorong
;
Du Daohai
;
Hu Junchi
;
Li Lianchun
;
Liu Jingqiu
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2020/07/01
PRC2
EZH2
EED
protein-protein interaction
fluorescence polarization
high-throughput screening
apomorphine hydrochloride
oxyphenbutazone
nifedipine
ergonovine maleate
Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2015, 卷号: 36, 期号: 1, 页码: 181-187
作者:
Yin, Nuoya
;
Yao, Xinglei
;
Qin, Zhanfen
;
Wang, Yuan-Liang
;
Faiola, Francesco
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2016/03/10
Bisphenol A (BPA)
Stem cell toxicology
Neurotoxicity
Embryonic stem cells (ESCs)
Developmental toxicity
Neural ectoderm
Intrinsic regulations in neural fate commitment
期刊论文
DEVELOPMENT GROWTH & DIFFERENTIATION, 2015, 卷号: 57, 期号: 2, 页码: 109-120
作者:
Tang, K
;
Peng, GD
;
Qiao, YB
;
Song, L
;
Jing, NH
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2015/07/22
embryonic stem cell
epigenetic modification
extracellular signals
neural fate commitment
transcription factor
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