CORC

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CORC

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Identification of catalytic and non-catalytic activity inhibitors against PRC2-EZH2 complex through multiple high-throughput screening campaigns 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2020, 页码: 27
作者:  Zhou, Yan;  Du, Dao-Hai;  Wang, Jia;  Cai, Xiao-Qing;  Deng, Alicia X.
收藏  |  浏览/下载：102/0  |  提交时间：2020/07/01
Identification and Assessments of Novel and Potent Small-Molecule Inhibitors of EED-EZH2 Interaction of Polycomb Repressive Complex 2 by Computational Methods and Biological Evaluations 期刊论文
CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 卷号: 68, 期号: 1, 页码: 58-63
作者:  Zhu, Kongkai;  Du, Daohai;  Yang, Rui;  Tao, Hongrui;  Zhang, Hua
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01
The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein-Protein Interaction 期刊论文
CURRENT MEDICINAL CHEMISTRY, 2020, 卷号: 27, 期号: 33, 页码: 5530-5542
作者:  Ye, Xiaoqing;  Chen, Gang;  Jin, Jia;  Zhang, Binzhong;  Wang, Yinda
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/24
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:  Zhang, Kai-li;  Shen, Qian-qian;  Fang, Yan-fen;  Sun, Yi-ming;  Ding, Jian
收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01
Targeting epigenetic machinery: Emerging novel allosteric inhibitors 期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:  Ye, Fei;  Huang, Jing;  Wang, Hongbo;  Luo, Cheng;  Zhao, Kehao
收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01
C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 11, 页码: 1457-1465
作者:  Shi, Yi;  Ma, Hong-lei;  Zhuang, You-wen;  Wang, Xiao-xi;  Jiang, Yi
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01
c10orf12modulatesprc2histonemethyltransferaseactivityandh3k27me3levels 期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 11, 页码: 1457
作者:  Shi Yi;  Ma Honglei;  Zhuang Youwen;  Wang Xiaoxi;  Jiang Yi
收藏  |  浏览/下载：9/0  |  提交时间：2020/07/01
Identification of 5-benzylidene-2-phenylthiazolones as potent PRMT5 inhibitors by virtual screening, structural optimization and biological evaluations 期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81, 页码: 289-298
作者:  Zhu, Kongkai;  Tao, Hongrui;  Song, Jia-Li;  Jin, Lu;  Zhang, Yuanyuan
收藏  |  浏览/下载：129/0  |  提交时间：2019/01/08
In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 17, 页码: E3978-E3986
作者:  Wu, Qibiao;  Tian, Yahui;  Zhang, Jian;  Tong, Xinyuan;  Huang, Hsinyi
收藏  |  浏览/下载：68/0  |  提交时间：2018/10/10
Development of a high-throughput fluorescence polarization assay for the discovery of EZH2-EED interaction inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 302-310
作者:  Zhu, Mao-rong;  Du, Dao-hai;  Hu, Jun-chi;  Li, Lian-chun;  Liu, Jing-qiu
收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08

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