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浏览/检索结果: 共20条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan 收藏  |  浏览/下载：85/0  |  提交时间：2020/12/24 RORγ  t  cocrystal structures  MD simulation  “  short”  inverse agonists  agonists  “  long”  inverse agonists   Identification of SARS-CoV-2 entry inhibitors among already approved drugs 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7 作者:  Yang, Li;  Pei, Rong-juan;  Li, Heng;  Ma, Xin-na;  Zhou, Yu 收藏  |  浏览/下载：42/0  |  提交时间：2020/12/24 COVID-19  SARS-CoV-2  virus entry inhibitors  high throughput screening assay  approved drug library  histamine receptor antagonists  clemastine   The artemisinin analog SM934 alleviates dry eye disease in rodent models by regulating TLR4/NF-kappa B/NLRP3 signaling 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yang, Fang-ming;  Fan, Di;  Yang, Xiao-qian;  Zhu, Feng-hua;  Shao, Mei-juan 收藏  |  浏览/下载：26/0  |  提交时间：2020/12/24 dry eye disease  artemisinin derivative  beta-aminoarteether maleate  inflammation  macrophages  TLR4  inflammasome   Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856 作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu 收藏  |  浏览/下载：237/0  |  提交时间：2020/12/24 Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)  hepatic steatosis  insulin resistance  caspase-1  interleukin 18 (IL-18)  fatty liver  metabolic disorder  inflammation  cytokine signaling  caspase 1 (CASP1)  tyrosine-protein phosphatase (tyrosine phosphatase)  macrophage   Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Yu, Yan-yan;  Cui, Shi-chao;  Zheng, Tian-nan;  Ma, Hai-jian;  Xie, Zhi-fu 收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 insulin resistance  sarsasapogenin  adipose tissue inflammation  macrophage-adipocyte crosstalk  IKK/NF-kappa B  JNK   MT1-MMP-Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy 期刊论文 ADVANCED SCIENCE, 2020, 页码: 14 作者:  Wei, Yan;  Song, Sha;  Duan, Nianxiu;  Wang, Feng;  Wang, Yuxi 收藏  |  浏览/下载：93/0  |  提交时间：2020/12/24 membrane type 1-matrix metalloproteinase-activated cilengitide  pancreatic cancer  smart liposomes  vascular promotion   DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15 作者:  Li, Heng;  Li, Jian;  Zhang, Xianglei;  Feng, Chunlan;  Fan, Chen 收藏  |  浏览/下载：28/0  |  提交时间：2020/12/24 DC591017  PDE4  Inflammation  Macrophages  Dendritic cells  Psoriasis   DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling 期刊论文 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15 作者:  Li, Heng;  Li, Jian;  Zhang, Xianglei;  Feng, Chunlan;  Fan, Chen 收藏  |  浏览/下载：40/0  |  提交时间：2020/12/24 DC591017  PDE4  Inflammation  Macrophages  Dendritic cells  Psoriasis   A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe 期刊论文 Journal of Experimental & Clinical Cancer Research, 2020, 卷号: 39, 期号: 1 作者:  Hu,Liangning;  Li,Bo;  Chen,Gege;  Song,Dongliang;  Xu,Zhijian 收藏  |  浏览/下载：94/0  |  提交时间：2020/07/01 Multiple myeloma  Drug-resistance  DNA damage response  Cell cycle   Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 99, 页码: 5 作者:  Wang, Xiao-Feng;  Zhu, Zhengdan;  Hao, Ting-Ting;  Fang, Qiang-Qiang;  Jiang, Kun 收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 Sophora alopecuroides  Alkaloids  Cl-containing matrines  Absolute configuration  Immunosuppressive activity