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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers 期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:  Lu, Xuxiu;  Yu, Rilei;  Li, Zhen;  Yang, Mengke;  Dai, Jiajia
收藏  |  浏览/下载:2/0  |  提交时间:2024/04/07
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia;  Feng, Bo;  Zhang, Chun
收藏  |  浏览/下载:30/0  |  提交时间:2021/12/01
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun
收藏  |  浏览/下载:187/0  |  提交时间:2021/11/04
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:  Liu, Wen;  Yin, Ye;  Wang, Meijing;  Fan, Ting;  Zhu, Yuyu
收藏  |  浏览/下载:182/0  |  提交时间:2020/12/24
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:  Satheeshkumar, Rajendran;  Zhu, Rui;  Feng, Bo;  Huang, Chao;  Gao, Ya
收藏  |  浏览/下载:29/0  |  提交时间:2020/07/01
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla 期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:  Jiang, Wei;  Xiong, Juan;  Zang, Yi;  Li, Junmin;  Osman, Ezzat E. A.
收藏  |  浏览/下载:83/0  |  提交时间:2020/07/01
Benzo[c][1,2,5] thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5154-5157
作者:  Wang, Wen-Long;  Chen, Xiao-Yu;  Gao, Ya;  Gao, Li-Xin;  Sheng, Li
收藏  |  浏览/下载:28/0  |  提交时间:2019/01/08
Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase 期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 69, 页码: 113734-113748
作者:  Igbe, I;  Shen, XF;  Jiao, W;  Qiang, Z;  Deng, T
收藏  |  浏览/下载:58/0  |  提交时间:2018/08/28
Quercetin  Interferon  Shp2  Jak  Stat  
Synthesis of Aromatic Amide Derivatives and Their Biological Evaluation against Protein Tyrosine Phosphatase 1B and Scr Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 9, 页码: 2142-2149
作者:  Wang Wenlong;  Luo Huan;  Gao Ya;  Gao Lixin;  Sheng Li
收藏  |  浏览/下载:22/0  |  提交时间:2019/01/08
synthesisofaromaticamidederivativesandtheirbiologicalevaluationagainstproteintyrosinephosphatase1bandscrhomology2domaincontainingproteintyrosinephosphatase2 期刊论文
chinesejournaloforganicchemistry, 2016, 卷号: 36, 期号: 9, 页码: 2142
作者:  Wang WL(王文龙);  Luo H(骆欢);  Gao Y(高雅);  Gao LX(高立信);  Sheng L(盛丽)
收藏  |  浏览/下载:1/0  |  提交时间:2020/07/01


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