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科研机构
上海药物研究所 [8]
厦门大学 [2]
成都生物研究所 [1]
海洋研究所 [1]
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期刊论文 [11]
学位论文 [1]
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2024 [1]
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2016 [2]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:187/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
收藏
  |  
浏览/下载:182/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
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  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
Benzo[c][1,2,5] thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5154-5157
作者:
Wang, Wen-Long
;
Chen, Xiao-Yu
;
Gao, Ya
;
Gao, Li-Xin
;
Sheng, Li
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Benzo[c][1,2,5] thiadiazole derivatives
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 69, 页码: 113734-113748
作者:
Igbe, I
;
Shen, XF
;
Jiao, W
;
Qiang, Z
;
Deng, T
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2018/08/28
Quercetin
Interferon
Shp2
Jak
Stat
Synthesis of Aromatic Amide Derivatives and Their Biological Evaluation against Protein Tyrosine Phosphatase 1B and Scr Homology-2 Domain Containing Protein Tyrosine Phosphatase-2
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 卷号: 36, 期号: 9, 页码: 2142-2149
作者:
Wang Wenlong
;
Luo Huan
;
Gao Ya
;
Gao Lixin
;
Sheng Li
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
PTP1B
SHP2
aromatic amide derivatives
inhibitors
synthesisofaromaticamidederivativesandtheirbiologicalevaluationagainstproteintyrosinephosphatase1bandscrhomology2domaincontainingproteintyrosinephosphatase2
期刊论文
chinesejournaloforganicchemistry, 2016, 卷号: 36, 期号: 9, 页码: 2142
作者:
Wang WL(王文龙)
;
Luo H(骆欢)
;
Gao Y(高雅)
;
Gao LX(高立信)
;
Sheng L(盛丽)
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/07/01
OLEANOLIC ACID
INHIBITORS
PTP1B
PTP1B
SHP2
aromatic amide derivatives
inhibitors
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