Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides | |
Wang, Xiao-Feng1,2; Zhu, Zhengdan1,3; Hao, Ting-Ting4,5; Fang, Qiang-Qiang1,2; Jiang, Kun2; Qu, Shi-Jin2; Zuo, Jiang-Pin1,4; Zhu, Weiliang1,3; He, Shi-Jun1,4; Tan, Chang-Heng1,2 | |
刊名 | BIOORGANIC CHEMISTRY |
2020-06-01 | |
卷号 | 99页码:5 |
关键词 | Sophora alopecuroides Alkaloids Cl-containing matrines Absolute configuration Immunosuppressive activity |
ISSN号 | 0045-2068 |
DOI | 10.1016/j.bioorg.2020.103812 |
通讯作者 | He, Shi-Jun(heshijun@simm.ac.cn) ; Tan, Chang-Heng(chtan@simm.ac.cn) |
英文摘要 | Alopecines A-E (1-5), five unusual matrine-type alkaloids featuring with an additional dichlorocyclopropane (1-3) or a di/tri-chloromethyl (4/5) attached on the D ring, were isolated from the seeds of Sophora alopecuroides. Their structures and absolute configurations were elucidated by extensive spectroscopic techniques, and X-ray diffraction analyses or time-dependent density functional theory-based electronic circular dichroism (TDDFT-ECD) calculations. Alkaloid 4 exhibited potent inhibitory effects on the proliferation of ConA-induced T lymphocytes or LPS-induced B cells with IC50 value of 3.98 or 3.74 mu M, respectively. |
资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09735001-002-005] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2019ZX09201001] ; Ministry of Science and Technology, China |
WOS关键词 | HBV ; DERIVATIVES ; PLANT |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:000535442000005 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/280084] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | He, Shi-Jun; Tan, Chang-Heng |
作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xiao-Feng,Zhu, Zhengdan,Hao, Ting-Ting,et al. Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides[J]. BIOORGANIC CHEMISTRY,2020,99:5. |
APA | Wang, Xiao-Feng.,Zhu, Zhengdan.,Hao, Ting-Ting.,Fang, Qiang-Qiang.,Jiang, Kun.,...&Tan, Chang-Heng.(2020).Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides.BIOORGANIC CHEMISTRY,99,5. |
MLA | Wang, Xiao-Feng,et al."Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides".BIOORGANIC CHEMISTRY 99(2020):5. |
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