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科研机构
上海药物研究所 [11]
兰州大学 [1]
山东大学 [1]
复旦大学上海医学院 [1]
内容类型
期刊论文 [13]
会议论文 [1]
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2021 [1]
2020 [1]
2019 [2]
2018 [2]
2016 [4]
2014 [1]
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浏览/检索结果:
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2018, 卷号: 31, 期号: 11, 页码: 1213-1218
作者:
Zhan, Zhengsheng
;
Peng, Xia
;
Sun, Yiming
;
Ai, Jing
;
Duan, Wenhu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Transcriptome sequencing identifies key pathways and genes involved in gastric adenocarcinoma
期刊论文
MOLECULAR MEDICINE REPORTS, 2018, 卷号: 18, 期号: 4, 页码: 3673-3682
作者:
Zhang, Wenhu
;
Liu, Shaozhuang
;
Zhan, Hanxiang
;
Yan, Zhibo
;
Zhang, Guangyong
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
gastric adenocarcinoma
differentially expressed genes
clustering
analysis
prognosis
Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 117, 页码: 47-58
作者:
Zhan, Wenhu
;
Xu, Lei
;
Dong, Xiaowu
;
Dong, Jun
;
Yi, Xiao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Akt1 inhibitor
Synthesis
Cytotoxicity
Molecular docking
Cancer
Discovery of 6-(difluoro(6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b] [1,2,4]triazin-3-yl)methyl)quinoline as a highly potent and selective c-Met inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 116, 页码: 239-251
作者:
Zhan, Zhengsheng
;
Peng, Xia
;
Liu, Qiufeng
;
Chen, Fang
;
Ji, Yinchun
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Antitumor
c-Met
Kinase inhibitor
Triazolotriazines
Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 25, 页码: 38091-38104
作者:
Wang, Ying
;
Zhan, Zhengsheng
;
Jiang, Xifei
;
Peng, Xia
;
Shen, Yanyan
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/01/08
c-Met
kinase inhibitor
Simm530
Simm530, a novel and highly selective c-Met inhibitor, blocks c-Met-stimulated signaling and neoplastic activities
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 25
作者:
Wang, Ying
;
Zhan, Zhengsheng
;
Jiang, Xifei
;
Peng, Xia
;
Shen, Yanyan
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/06
c-Met
kinase inhibitor
Simm530
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