CORC

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CORC

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：20/0  |  提交时间：2022/01/04
Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663
作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong
收藏  |  浏览/下载：14/0  |  提交时间：2021/12/16
Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14
作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei
收藏  |  浏览/下载：37/0  |  提交时间：2021/08/17
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue
收藏  |  浏览/下载：20/0  |  提交时间：2020/12/21
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:  Che, Jinxin;  Huang, Feng;  Zhang, Mengmeng;  Xu, Gaoya;  Qu, Bingxue
收藏  |  浏览/下载：21/0  |  提交时间：2020/12/21
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:  Zhan, Wenhu;  Che, Jinxin;  Xu, Lei;  Wu, Yizhe;  Hu, Xiaobei
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 18
作者:  Wu, Lingyan;  Xia, Mingfeng;  Duan, Yanan;  Zhang, Lina;  Jiang, Haowen
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10
作者:  Wu, Lingyan;  Xia, Mingfeng;  Duan, Yanan;  Zhang, Lina;  Jiang, Haowen
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/05
CagA increases DNA methylation and decreases PTEN expression in human gastric cancer 期刊论文
MOLECULAR MEDICINE REPORTS, 2019, 卷号: 19, 期号: 1
作者:  Zhang, Baogui;  Zhang, Xiaobei;  Jin, Meng;  Hu, Lei;  Zang, Mingde
收藏  |  浏览/下载：27/0  |  提交时间：2019/12/05

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