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上海药物研究所 [25]
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The unconventional prefoldin RPB5 interactor mediates the gravitropic response by modulating cytoskeleton organization and auxin transport in Arabidopsis
期刊论文
JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2022, 卷号: 64, 期号: 10, 页码: 1916-1934
作者:
Yang, Yi
;
Liu, Fang
;
Liu, Le
;
Zhu, Mingyue
;
Yuan, Jinfeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/07
Arabidopsis
auxin
cytoskeleton
PIN2
prefoldin (PFD)
unconventional prefoldin RPB5 interactor (URI)
Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5
作者:
Wang, Leiming
;
Li, Xin
;
Cui, Hong
;
Lei, Xinsheng
;
Liu, Hongchun
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/12/01
Marine nature products
Plocabulin
PM060184
Synthesis
Antiproliferation
Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora
期刊论文
PLANTA MEDICA, 2021, 页码: 7
作者:
Lei, Chun
;
Li, Ya-Nan
;
Li, Jia-Nan
;
Zhou, Yu-Bo
;
Cui, Ming-Jun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/16
Trewia nudiflora
Euphorbiaceae
maytansinoids
cytotoxicity
tubulin polymerization
Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Zhou, Yu-bo
;
Zhang, Yang-ming
;
Huang, Hong-hui
;
Shen, Li-jing
;
Han, Xiao-feng
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
multiple myeloma
HDAC inhibitor
bisthianostat
pharmacodynamics
pharmacokinetics
phase 1a clinical trial
antitumor drug
1-Phenyl-dihydrobenzoindazoles as novel colchicine site inhibitors: Structural basis and antitumor efficacy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 177, 页码: 448-456
作者:
Jiang, Junhang
;
Zhang, Hao
;
Wang, Chongqing
;
Zhang, Qingsen
;
Fang, Shaoyu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Microtubule-targeting agents
Colchicine site inhibitors
Cis-trans photoisomerization
X-ray co-crystal structure
Water-soluble prodrug
Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 3
作者:
Shi, Tian-Qi
;
Wang, Yan-Ting
;
Liu, Chang-Hong
;
Zhu, Hai-Liang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Benzimidazole
Benzsulfamide
Pyrazole
Tubulin
Inhibition
Apoptosis
Molecular docking
3,5-Diaryl-1H-pyrazolo[3,4-b]pyridines as potent tubulin polymerization inhibitors: Rational design, synthesis and biological evaluation
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: Vol.168, 页码: 426-435
作者:
Min'an Zhai
;
Shiyuan Liu
;
Meiqi Gao
;
Long Wang
;
Jun Sun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Ring tethering
Conformational analysis
Pyrazolo[3,4-b]pyridine
Colchicine site
Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Cui, Ying-Jie
;
Tang, Long-Qian
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2019/12/11
privileged structure
pyrazoles
tubulin inhibitors
antitumor
antitumor agents
Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 7, 页码: 659-664
作者:
Liu, Guangpu
;
Jiao, Yang
;
Huang, Chunxi
;
Chang, Ping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Microtubules inhibitors
Anticancer target
Colchicine binding site
Drug discovery
Molecular docking
Synthesis, molecular properties prediction and biological evaluation of indole-vinyl sulfone derivatives as novel tubulin polymerization inhibitors targeting the colchicine binding site
期刊论文
Bioorganic Chemistry, 2019, 卷号: Vol.85, 页码: 49-59
作者:
Wenlong Li
;
Honghao Sun
;
Feijie Xu
;
Wen Shuai
;
Jie Liu
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/12/13
Tubulin
inhibitor
Vinyl
sulfone
Indole
Colchicine
site
Drug-likeness
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