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上海药物研究所 [16]
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期刊论文 [32]
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Hollow structures as drug carriers: Recognition, response, and release
期刊论文
NANO RESEARCH, 2021, 页码: 19
作者:
Zhao, Decai
;
Yang, Nailiang
;
Xu, Lekai
;
Du, Jiang
;
Yang, Yang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/08/31
hollow structure
drug delivery system
carriers
spatiotemporal
Design, Synthesis, and Biological Activities of Novel Triazolothiadiazole Derivatives Linked with Amino Side Chain Containing Urea Group as DOT1L Inhibitors
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 卷号: 40, 期号: 8, 页码: 2450-2459
作者:
Liu Na
;
Guo Siqi
;
Liu Junfang
;
Chen Yantao
;
Xu Xiaoming
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  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
DOT1L inhibitor
triazolothiadiazole
triazolothiadiazine
nucleophilic substitution
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant
期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 5, 页码: 1281-1287
作者:
Hu, Xianglong
;
Xun, Qiuju
;
Zhang, Tao
;
Zhu, Su-Jie
;
Li, Qian
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
EGFR(C797S) mutant
SARs
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidine
Clinical resistance
Fourth-generation inhibitors
Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Cui, Ying-Jie
;
Tang, Long-Qian
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
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  |  
浏览/下载:122/0
  |  
提交时间:2019/12/11
privileged structure
pyrazoles
tubulin inhibitors
antitumor
antitumor agents
Indole: A privileged scaffold for the design of anti-cancer agents
期刊论文
European Journal of Medicinal Chemistry, 2019, 卷号: 183
作者:
Wan Y.
;
Li Y.
;
Yan C.
;
Yan M.
;
Tang Z.
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/11
Anti-Cancer
Drug design
Indole
Structure-activity relationships
Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy
期刊论文
2019, 卷号: 74, 期号: 5, 页码: 265-269
作者:
Jiang, Jing
;
Zhao, Xiaoqiang
;
Niu, Tianyu
;
Yan, Haiyan
;
Li, Yinghong
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  |  
浏览/下载:7/0
  |  
提交时间:2020/01/03
Discovery and structure-activity relationships study of thieno[2,3-b] pyridine analogues as hepatic gluconeogenesis inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 307-317
作者:
Ma, Fei
;
Liu, Jian
;
Zhou, Tingting
;
Lei, Min
;
Chen, Jing
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  |  
浏览/下载:78/0
  |  
提交时间:2019/01/08
Thienol2,3-b]pyridine derivatives
Structure-activity relationships (SARs)
Hepatic gluconeogenesis
Type 2 diabetes mellitus (T2DM)
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724
作者:
Sun, Lin
;
Gao, Ping
;
Dong, Guanyu
;
Zhang, Xujie
;
Cheng, Xiqiang
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  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HAART
HIV-1 dual inhibitors
HIV-1 IN
RNase H
5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives
Privileged
structure
Aminobenzisoxazole compounds as agonists of alpha 7 nicotinic acetylcholine receptors: a patent evaluation (WO 2017027600)
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 卷号: 28, 期号: 5, 页码: 429-436
作者:
He, Yang
;
Shen, Jingshan
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Nicotinic receptors
alpha 7 nAchR
cognition
agonists
allosteric modulators
Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 卷号: 27, 期号: 11, 页码: 1277-1286
作者:
Cheng, Xiqiang
;
Gao, Ping
;
Sun, Lin
;
Tian, Ye
;
Zhan, Peng
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/12
AIDS
HIV-1
IN inhibitors
prodrug
privileged structure
drug design
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