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Phylogenetic Analysis and Characterization of Diguanylate Cyclase and Phosphodiesterase in Planktonic Filamentous Cyanobacterium
Arthrospira
sp.
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 20, 页码: 11
作者:
Wang, Kang
;
Li, Wenjun
;
Cui, Hongli
;
Qin, Song
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/01/26
c-di-GMP
Arthrospira
diguanylate cyclase
phosphodiesterase
riboswitch
Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation
期刊论文
JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251
作者:
Li, Heng
;
Zhang, Xianglei
;
Xiang, Caigui
;
Feng, Chunlan
;
Fan, Chen
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  |  
浏览/下载:84/0
  |  
提交时间:2021/11/04
PDE4
Arctigenin
Psoriasis
Inflammation
Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Lu, Qiu-kai
;
Fan, Chen
;
Xiang, Cai-gui
;
Wu, Bing
;
Lu, Hui-min
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  |  
浏览/下载:57/0
  |  
提交时间:2021/06/11
PDE4
apremilast
skin fibrosis
macrophages
Crop residue application at low rates could improve soil phosphorus cycling under long-term no-tillage management
期刊论文
BIOLOGY AND FERTILITY OF SOILS, 2021, 页码: 13
作者:
Wu, Guohui
;
Wei, Kai
;
Chen, Zhenhua
;
Jiang, Dongqi
;
Xie, Hongtu
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2021/03/29
Phosphatase activities
Soil P species
P-31 NMR spectroscopy
No-tillage
Residue application rates
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20
作者:
Zhang, Rui
;
Li, Heng
;
Zhang, Xianglei
;
Li, Jian
;
Su, Haixia
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  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
PDE4 inhibitors
Tetrahydroisoquinoline
Antipsoriasis
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
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  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:
Zhang, Mengqi
;
Liu, Haiming
;
He, Jiajin
;
Gui, Yuzhou
;
Qian, Hongjie
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  |  
浏览/下载:29/0
  |  
提交时间:2020/12/24
TPN171
LC-MS/MS
Human plasma
Protein precipitation
Therapy for Apnoea of Prematurity: A Retrospective Study on Effects of Standard Dose and Genetic Variability on Clinical Response to Caffeine Citrate in Chinese Preterm Infants
期刊论文
ADVANCES IN THERAPY, 2020, 页码: 20
作者:
He, Xin
;
Qiu, Jin-Chun
;
Lu, Ke-Yu
;
Guo, Hong-Li
;
Li, Ling
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
Adenosine receptors
AHR
AOP
Caffeine
Phosphodiesterase
Polymorphism
Therapeutic drug monitoring
Activation of SIK1 by phanginin A inhibits hepatic gluconeogenesis by increasing PDE4 activity and suppressing the cAMP signaling pathway
期刊论文
MOLECULAR METABOLISM, 2020, 卷号: 41, 页码: 15
作者:
Liu, Siwen
;
Huang, Suling
;
Wu, Xingde
;
Feng, Ying
;
Shen, Yu
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
Salt-inducible kinase 1
Phanginin A
Phosphodiesterase 4
Gluconeogenesis
cAMP
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
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