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Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway
期刊论文
PHYTOMEDICINE, 2023, 卷号: 108
作者:
Hu, Yiqun
;
Wen, Qingliang
;
Cai, Yefeng
;
Liu, Yunye
;
Ma, Wenli
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浏览/下载:196/0
  |  
提交时间:2022/12/23
Alantolactone
Anaplastic thyroid cancer
ROS
Pyroptosis
Apoptosis
Sheep tail fat inhibits the proliferation of non-small-cell lung cancer cells in vitro and in vivo
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Xu, Changzhi
;
Zhang, Lanlan
;
He, Huimin
;
Liu, Xiaoyi
;
Pei, Xinxin
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  |  
浏览/下载:28/0
  |  
提交时间:2022/12/23
sheep tail fat
non-small-cell lung cancer
heptadecanoic acid
antiproliferative effect
Akt
S6K signaling pathway
BRD4 Targets the KEAP1-Nrf2-G6PD Axis and Suppresses Redox Metabolism in Small Cell Lung Cancer
期刊论文
ANTIOXIDANTS, 2022, 卷号: 11
作者:
Lv, Yang
;
Lv, Xiaotong
;
Zhang, Jiahui
;
Cao, Guozhen
;
Xu, Changzhi
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2022/05/16
small cell lung cancer
BRD4
KEAP1
Nrf2
pentose phosphate pathway
Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]- pyrrolo[1,2-a]pyrimidinones
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 2, 页码: 543-556
作者:
Zeng, Y (Zeng Yan) [1] , [2]
;
Nie, LF (Nie Lifei) [1]
;
Niu, C (Niu Chao) [1]
;
Mamatjan, A (Mamatjan Aytilla) [1] , [2]
;
Bozorov, K (Bozorov Khurshed) [1]
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  |  
浏览/下载:23/0
  |  
提交时间:2022/05/17
oxazopyrimidinone
synthesis
bioisosterism
anticancer activity
antimicrobial activity
structure-activity relationships (SARs)
Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 60
作者:
Luo, T
;
Li, Z
;
Deng, XM
;
Jiang, K
;
Liu, D
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  |  
浏览/下载:9/0
  |  
提交时间:2022/12/02
Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 228
作者:
Deng, XM
;
Luo, T
;
Li, Z
;
Wen, HX
;
Zhang, HH
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  |  
浏览/下载:13/0
  |  
提交时间:2022/12/02
Design, synthesis, and biological evaluation of 4-benzoylamino-1H-pyrazole-3-carboxamide derivatives as potent CDK2 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 12
作者:
Lin, Tingting
;
Li, Jiacheng
;
Liu, Liping
;
Li, Yuanqing
;
Jiang, Hualiang
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  |  
浏览/下载:70/0
  |  
提交时间:2021/05/24
CDK2 inhibitor
Selectivity
Anti-proliferative potency
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
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  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 13
作者:
Wang, Yuhong
;
Mi, Tian
;
Li, Yiming
;
Kan, Weijuan
;
Xu, Gaoya
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Lenalidomide
Multiple myeloma
MM.1S
Late-stage sulfuration
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
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  |  
浏览/下载:22/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
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