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科研机构
山东大学 [37]
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期刊论文 [33]
学位论文 [3]
会议论文 [1]
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2019 [5]
2018 [1]
2017 [1]
2016 [7]
2015 [6]
2013 [1]
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专题:山东大学
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Synthesis of Novel Pyrazole Derivatives and Their Tumor Cell Growth Inhibitory Activity
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 2
作者:
Cui, Ying-Jie
;
Tang, Long-Qian
;
Zhang, Cheng-Mei
;
Liu, Zhao-Peng
收藏
  |  
浏览/下载:122/0
  |  
提交时间:2019/12/11
privileged structure
pyrazoles
tubulin inhibitors
antitumor
antitumor agents
Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 170, 页码: 73-86
作者:
Zhao, Wei
;
He, Long
;
Xiang, Tian-Le
;
Tang, Ya-Jie
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
Tubulin
Colchicine domain
Podophyllotoxin
Binding affinity
Nanomolar-potency antitumor activity
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
期刊论文
Investigational New Drugs, 2019
作者:
Wu J.-D.
;
Cui Y.-J.
;
Zhou Y.-G.
;
Tang L.-Q.
;
Zhang C.-M.
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hepatocellular carcinoma
Liver microsome stability
Multidrug-resistance
Pharmacokinetics
Tubulin polymerization inhibitor
Identification of novel and potent small-molecule inhibitors of tubulin with antitumor activities by virtual screening and biological evaluations
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 7, 页码: 659-664
作者:
Liu, Guangpu
;
Jiao, Yang
;
Huang, Chunxi
;
Chang, Ping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Microtubules inhibitors
Anticancer target
Colchicine binding site
Drug discovery
Molecular docking
Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
期刊论文
European Journal of Medicinal Chemistry, 2019, 页码: 73-86
作者:
Zhao W.
;
He L.
;
Xiang T.-L.
;
Tang Y.-J.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Binding affinity
Colchicine domain
Nanomolar-potency antitumor activity
Podophyllotoxin
Tubulin
PMN inhibits colorectal cancer cells through inducing mitotic arrest and p53-dependent apoptosis via the inhibition of tubulin polymerization
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 499, 期号: 4, 页码: 927-933
作者:
Wu, Xingkang
;
Shen, Yuemao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/11
PMN
Colorectal cancer
Mitotic arrest
Microtubule
Apoptosis
p53
Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 129, 页码: 186-208
作者:
Sun, Bin
;
Li, Lin
;
Hu, Qing-wen
;
Zheng, Hong-bo
;
Tang, Hui
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/12
Bisbibenzyls
Tubulin polymerization inhibitors
Anticancer
Molecular
modeling
A new method to effectively and rapidly generate neurons from SH-SY5Y cells
期刊论文
NEUROSCIENCE LETTERS, 2016, 卷号: 610, 页码: 43-47
作者:
Yang, HongNa
;
Wang, Jing
;
Sun, JinHua
;
Liu, XiaoDun
;
Duan, Wei-Ming
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/16
SH-SY5Y cells
RA
CM-hNSCs
Neurons
beta-tubulin III
Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 121, 页码: 484-499
作者:
Sun, Bin
;
Li, Lin
;
Hu, Qing-wen
;
Xie, Fei
;
Zheng, Hong-bo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
Marchantin C
Bisbibenzyls
Analogues
Tubulin polymerization
inhibitors
Anticancer
Knockdown of Tubulin Polymerization Promoting Protein Family Member 3 Suppresses Proliferation and Induces Apoptosis in Non-Small-Cell Lung Cancer
期刊论文
JOURNAL OF CANCER, 2016, 卷号: 7, 期号: 10, 页码: 1189-1196
作者:
Li, Yintao
;
Xu, Yali
;
Ye, Kuanping
;
Wu, Nan
;
Li, Junfeng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/16
TPPP3
NSCLC
cell proliferation
cell apoptosis
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