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Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
Zhao, Wei; He, Long; Xiang, Tian-Le; Tang, Ya-Jie
刊名EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2019
卷号170页码:73-86
关键词Tubulin Colchicine domain Podophyllotoxin Binding affinity Nanomolar-potency antitumor activity
DOI10.1016/j.ejmech.2019.03.006
URL标识查看原文
公开日期[db:dc_date_available]
内容类型期刊论文
URI标识http://www.corc.org.cn/handle/1471x/4536644
专题山东大学
作者单位1.Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China.
2.Hubei
推荐引用方式
GB/T 7714
Zhao, Wei,He, Long,Xiang, Tian-Le,et al. Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019,170:73-86.
APA Zhao, Wei,He, Long,Xiang, Tian-Le,&Tang, Ya-Jie.(2019).Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,170,73-86.
MLA Zhao, Wei,et al."Discover 4 beta-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 170(2019):73-86.
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