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科研机构
上海药物研究所 [185]
内容类型
期刊论文 [183]
会议论文 [2]
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2022 [1]
2021 [7]
2020 [6]
2018 [5]
2017 [4]
2016 [9]
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学科主题
Chemistry [11]
Spectrosco... [7]
Biochemist... [6]
Pharmacolo... [2]
Physics [1]
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Spatial lipidomics of eight edible nuts by desorption electrospray ionization with ion mobility mass spectrometry imaging
期刊论文
FOOD CHEMISTRY, 2022, 卷号: 371, 页码: 11
作者:
Hou, Jinjun
;
Zhang, Zijia
;
Zhang, Linlin
;
Wu, Wenyong
;
Huang, Yong
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2021/12/16
Desorption electrospray ionization (DESI)
Mass spectrometry imaging (MSI)
Ion mobility
Collision cross section (CCS)
Nuts
Phospholipids
Fatty acid derivatives
Distribution profiles
Desorption electrospray ionization (DESI) source coupling ion mobility mass spectrometry for imaging fluoropezil (DC20) distribution in rat brain
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 页码: 13
作者:
Guo, Runcong
;
Zhou, Lei
;
Chen, Xiaoyan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/11/04
DESI
Mass spectrometry imaging
Fluoropezil (DC20)
Brain distribution
Optimization strategy
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Pan, Lu-lu
;
Chen, Tao
;
Hui, Min
;
Wang, Shuo
;
Fu, Li
收藏
  |  
浏览/下载:131/0
  |  
提交时间:2021/05/24
LC-MS/MS
Forsythin
Aglycone glucuronide
Aglycone sulfate
Pharmacokinetics
Exploration of tissue distribution of ginsenoside Rg1 by LC-MS/MS and nanospray desorption electrospray ionization mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Wei, Wenlong
;
Li, Zhenwei
;
Li, Haojv
;
An, Yaling
;
Qu, Hua
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/05/24
Ginsenoside Rg1
Nanospray desorption electrospray ionization
Tissue distribution
Spatial distribution
Challenges and stepwise fit-for-purpose optimization for bioanalyses of remdesivir metabolites nucleotide monophosphate and triphosphate in mouse tissues using LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 194, 页码: 10
作者:
Hu, Wenjuan
;
Chang, Lu
;
Ke, Changqiang
;
Xie, Yuanchao
;
Shen, Jingshan
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Remdesivir
Nucleotide monophosphate
Nucleotide triphosphate
Stability
Recovery
LC-MS/MS
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
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  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Characterization and quantitative determination of henagliflozin metabolites in humans
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 192, 页码: 8
作者:
Chen, Zhendong
;
Li, Liang
;
Zhan, Yan
;
Zhang, Yifan
;
Liu, Haiyan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Henagliflozin
Metabolism
LC-MS/MS
Simultaneous determination of sutetinib and its active metabolite sutetinibN-oxide in human plasma by liquid chromatography-tandem mass spectrometry: Evaluation of plasma stability
期刊论文
BIOMEDICAL CHROMATOGRAPHY, 2020, 页码: 9
作者:
Qiu, Yanan
;
Tang, Chongzhuang
;
Li, Ranran
;
Cao, Sumin
;
Zhang, Yuqiang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
LC-MS
MS
N-oxide
stability
sutetinib
A rapid and convenient derivatization method for quantitation of short-chain fatty acids in human feces by ultra-performance liquid chromatography/tandem mass spectrometry
期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2020, 卷号: 34, 期号: 9, 页码: 11
作者:
Fu, Huan
;
Zhang, Qing-li
;
Huang, Xiao-wu
;
Ma, Zheng-hua
;
Zheng, Xiao-li
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
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