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合肥物质科学研究院 [6]
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期刊论文 [21]
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2022 [21]
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Development of a novel PROTAC using the nucleic acid aptamer as a targeting ligand for tumor selective degradation of nucleolin
期刊论文
MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 卷号: 30
作者:
Zhang, Lin
;
Li, Ling
;
Wang, Xia
;
Liu, Huimin
;
Zhang, Yibin
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  |  
浏览/下载:24/0
  |  
提交时间:2022/12/23
Deep Learning for Brain MRI Confirms Patterned Pathological Progression in Alzheimer's Disease
期刊论文
ADVANCED SCIENCE, 2022, 页码: 19
作者:
Pan, Dan
;
Zeng, An
;
Yang, Baoyao
;
Lai, Gangyong
;
Hu, Bing
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  |  
浏览/下载:14/0
  |  
提交时间:2023/02/22
Alzheimer's disease
deep learning
longitudinal trajectories of neurodegeneration
structural magnetic resonance imaging
Deep graph level anomaly detection with contrastive learning
期刊论文
SCIENTIFIC REPORTS, 2022, 卷号: 12, 期号: 1, 页码: 11
作者:
Luo, Xuexiong
;
Wu, Jia
;
Yang, Jian
;
Xue, Shan
;
Peng, Hao
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  |  
浏览/下载:14/0
  |  
提交时间:2023/02/07
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71
作者:
Li, Haobin
;
Cai, Maohua
;
Cao, Fei
;
Yu, Dehua
;
Yang, Jing
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  |  
浏览/下载:14/0
  |  
提交时间:2022/12/22
STAT3 inhibitor
Quinone derivative
S3I-201
Anti -gastric cancer drug
Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer
期刊论文
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 卷号: 12
作者:
Ying, Hua-Zhong
;
Xie, Wei
;
Wang, Meng-Chuan
;
He, Jia-Qi
;
Zhang, Huan-Huan
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  |  
浏览/下载:17/0
  |  
提交时间:2022/12/23
intestinal homeostasis
natural products
chronic inflammation
probiotic
immunoenhancement
tumor microenvironment
Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
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  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Stress in DNA Gridiron Facilitates the Formation of Two-Dimensional Crystalline Structures
期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2022, 卷号: 144
作者:
Yu, Lei
;
Cheng, Jin
;
Wang, Dongfang
;
Pan, Victor
;
Chang, Shuai
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  |  
浏览/下载:11/0
  |  
提交时间:2022/12/23
Structure-aware conditional variational auto-encoder for constrained molecule optimization
期刊论文
PATTERN RECOGNITION, 2022, 卷号: 126, 页码: 9
作者:
Yu, Junchi
;
Xu, Tingyang
;
Rong, Yu
;
Huang, Junzhou
;
He, Ran
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  |  
浏览/下载:17/0
  |  
提交时间:2022/06/06
Molecule optimization
Conditional generation
Drug discovery
Insights into intercellular receptor-ligand binding kinetics in cell communication
期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 10, 页码: 953353
作者:
An, Chenyi
;
Wang, Xiaohuan
;
Song F(宋凡)
;
Hu, Jinglei
;
Li L(李龙)
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/10/23
cell communication
intercellular receptor-ligand binding kinetics
protein-membrane interaction
biomechanical force
bioelectric microenvironment
GM-Pep: A High Efficiency Strategy to De Novo Design Functional Peptide Sequences
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2022, 卷号: 62, 期号: 10, 页码: 2617-2629
作者:
Chen, Qushuo
;
Yang, Changyan
;
Xie, Yihao
;
Wang, Yuqiang
;
Li, Xiaoxu
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/06/21
BioactivityDrug interactionsLearning systemsToxicity
Auto encodersComputation methodsDe novo designFunctional peptidesHigher efficiencyMulti-classifierPeptide sequencesPeptide therapeuticsTherapeutic agentsTherapeutic peptides
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