Insights into intercellular receptor-ligand binding kinetics in cell communication

doi:10.3389/fbioe.2022.953353

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Insights into intercellular receptor-ligand binding kinetics in cell communication
	An, Chenyi 4,9; Wang, Xiaohuan 8; Song F(宋凡); Hu, Jinglei 2,5; Li L(李龙)
刊名	FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
	2022-06
卷号	10 页码:953353
关键词	cell communication intercellular receptor-ligand binding kinetics protein-membrane interaction biomechanical force bioelectric microenvironment
ISSN号	2296-4185
DOI	10.3389/fbioe.2022.953353
英文摘要	Cell-cell communication is crucial for cells to sense, respond and adapt to environmental cues and stimuli. The intercellular communication process, which involves multiple length scales, is mediated by the specific binding of membrane-anchored receptors and ligands. Gaining insight into two-dimensional receptor-ligand binding kinetics is of great significance for understanding numerous physiological and pathological processes, and stimulating new strategies in drug design and discovery. To this end, extensive studies have been performed to illuminate the underlying mechanisms that control intercellular receptor-ligand binding kinetics via experiment, theoretical analysis and numerical simulation. It has been well established that the cellular microenvironment where the receptor-ligand interaction occurs plays a vital role. In this review, we focus on the advances regarding the regulatory effects of three factors including 1) protein-membrane interaction, 2) biomechanical force, and 3) bioelectric microenvironment to summarize the relevant experimental observations, underlying mechanisms, as well as their biomedical significances and applications. Meanwhile, we introduce modeling methods together with experiment technologies developed for dealing with issues at different scales. We also outline future directions to advance the field and highlight that building up systematic understandings for the coupling effects of these regulatory factors can greatly help pharmaceutical development.
学科主题	Biotechnology & Applied Microbiology ; Multidisciplinary Sciences
分类号	二类/Q1
语种	英语
WOS记录号	WOS:000823655300001
资助机构	National Natural Science Foundation of China [11902327, 11972041, 12102389, 22161132012, 21973040] ; Youth In11ation Promotion Association CAS, China Postdoctoral Science Foundation [2020M681834]
其他责任者	Li, L (corresponding author), Chinese Acad Sci, State Key Lab Nonlinear Mech, Beijing, Peoples R China. ; Hu, JL (corresponding author), Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China. ; Li, L (corresponding author), Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China. ; Hu, JL (corresponding author), Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China.
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/90166]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.Nanjing Univ, Inst Brain Sci, Nanjing, Peoples R China 2.Chinese Acad Sci, Inst Mech, Beijing Key Lab Engn Construct & Mechanobiol, Beijing, Peoples R China 3.Zhejiang Univ, Sch Med, Dept Cardiol, Affiliated Hosp 2, Hangzhou, Peoples R China 4.Nanjing Univ, Kuang Yaming Honors Sch, Nanjing, Peoples R China 5.Univ Chinese Acad Sci, Sch Engn Sci, Beijing, Peoples R China 6.Chinese Acad Sci, State Key Lab Nonlinear Mech, Beijing, Peoples R China 7.Peking Univ Third Hosp, Dept Rehabil Med, Beijing, Peoples R China 8.Zhejiang Univ, Sch Med, Dept Cell Biol, Hangzhou, Peoples R China 9.Guizhou Med Univ, Sch Biol & Engn, Guiyang, Peoples R China
推荐引用方式 GB/T 7714	An, Chenyi,Wang, Xiaohuan,Song F,et al. Insights into intercellular receptor-ligand binding kinetics in cell communication[J]. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,2022,10:953353.
APA	An, Chenyi,Wang, Xiaohuan,宋凡,Hu, Jinglei,&李龙.(2022).Insights into intercellular receptor-ligand binding kinetics in cell communication.FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY,10,953353.
MLA	An, Chenyi,et al."Insights into intercellular receptor-ligand binding kinetics in cell communication".FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY 10(2022):953353.