Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer

doi:10.3389/fcimb.2022.969526

	Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer
	Ying, Hua-Zhong 2; Xie, Wei 2; Wang, Meng-Chuan 2; He, Jia-Qi 3; Zhang, Huan-Huan 2; Yu, Chen-Huan 1,2,4
刊名	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
	2022-08-16
卷号	12
关键词	intestinal homeostasis natural products chronic inflammation probiotic immunoenhancement tumor microenvironment
ISSN号	2235-2988
DOI	10.3389/fcimb.2022.969526
通讯作者	Yu, Chen-Huan(yuchenhuan2002@163.com)
英文摘要	The gut dysbiosis has emerged as a prominent player in the pathogenesis and development of colorectal cancer (CRC), which in turn intensifies dysregulated gut microbiota composition and inflammation. Since most drugs are given orally, this dysbiosis directly and indirectly impinges the absorption and metabolism of drugs in the gastrointestinal tract, and subsequently affects the clinical outcome of patients with CRC. Herbal medicine, including the natural bioactive products, have been used traditionally for centuries and can be considered as novel medicinal sources for anticancer drug discovery. Due to their various structures and pharmacological effects, natural products have been found to improve microbiota composition, repair intestinal barrier and reduce inflammation in human and animal models of CRC. This review summarizes the chemo-preventive effects of extracts and/or compounds derived from natural herbs as the promising antineoplastic agents against CRC, and will provide innovative strategies to counteract dysregulated microbiota and improve the lives of CRC patients.
资助项目	National Natural Science Foundation of China ; Zhejiang province of medical science ; [82104526] ; [2022KY917]
WOS关键词	ULCERATIVE-COLITIS ; MICE ; BIOAVAILABILITY ; BERBERINE ; GINSENG ; RATS ; CARCINOGENESIS ; TUMORIGENESIS ; INHIBITION ; METABOLITE
WOS研究方向	Immunology ; Microbiology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000847858900001
资助机构	National Natural Science Foundation of China ; Zhejiang province of medical science
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/131846]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Chen-Huan
作者单位	1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Hangzhou, Peoples R China 2.Zhejiang Acad Med Sci, Hangzhou Med Coll, Key Lab Expt Anim & Safety Evaluat, Hangzhou, Peoples R China 3.Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Ying, Hua-Zhong,Xie, Wei,Wang, Meng-Chuan,et al. Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer[J]. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,2022,12.
APA	Ying, Hua-Zhong,Xie, Wei,Wang, Meng-Chuan,He, Jia-Qi,Zhang, Huan-Huan,&Yu, Chen-Huan.(2022).Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer.FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,12.
MLA	Ying, Hua-Zhong,et al."Gut microbiota: An emerging therapeutic approach of herbal medicine for prevention of colorectal cancer".FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 12(2022).