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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2019     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15 作者:  Lu, Wenchao;  Wang, Jun;  Li, Yong;  Tao, Hongru;  Xiong, Huan 收藏  |  浏览/下载：94/0  |  提交时间：2020/07/01 Hippo pathway  TEAD transcription factor  Covalent inhibitor  Palmitoylation inhibitor   AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595 作者:  Zhang, Kai-li;  Shen, Qian-qian;  Fang, Yan-fen;  Sun, Yi-ming;  Ding, Jian 收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 PRC2  EZH2-EED  AZD9291  miR-34a  non-canonical base pairing   Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine 期刊论文 CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13 作者:  Tian, Chang-Qing;  Chen, Lin;  Chen, Hua-Dong;  Huan, Xia-Juan;  Hu, Jian-Ping 收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 Inhibition of Ezh2 In Vitro and the Decline of Ezh2 in Developing Midbrain Promote Dopaminergic Neurons Differentiation Through Modifying H3K27me3 期刊论文 STEM CELLS AND DEVELOPMENT, 2019, 卷号: 28, 期号: 10, 页码: 649-658 作者:  Hong, Feng;  Zhao, Mengxue;  Zhang, Lei;  Feng, Linyin 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 dopaminergic neurons  Ezh2  Nurr1  neural stem cells   Deep Neural Network Classifier for Virtual Screening Inhibitors of (S)-Adenosyl-L-Methionine (SAM)-Dependent Methyltransferase Family 期刊论文 FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 17 作者:  Li, Fei;  Wan, Xiaozhe;  Xing, Jing;  Tan, Xiaoqin;  Li, Xutong 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 deep neural network  virtual screening  methyltransferase  epigenetic  drug design   Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells 期刊论文 CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 卷号: 32, 期号: 5, 页码: 861-868 作者:  Zhong, Shangwei;  Li, Cuiping;  Han, Xiao;  Li, Xiangjun;  Yang, Yun-Gui 收藏  |  浏览/下载：25/0  |  提交时间：2020/10/21 Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening 期刊论文 BIOORGANIC CHEMISTRY, 2019, 卷号: 86, 页码: 494-500 作者:  Zhang, Dan;  Han, Jie;  Lu, Wenchao;  Lian, Fulin;  Wang, Jun 收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01 Lysine acetylation  Bromodomain  Virtual screening  BPTF inhibitor   Discovery of Novel PRMT5 Inhibitors by Virtual Screening and Biological Evaluations 期刊论文 CHEMICAL & PHARMACEUTICAL BULLETIN, 2019, 卷号: 67, 期号: 4, 页码: 382-388 作者:  Tao, Hongrui;  Yan, Xue;  Zhu, Kongkai;  Zhang, Hua 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 virtual screening  epigenetic inhibitor  antiproliferation  molecular docking   Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 164, 页码: 317-333 作者:  Shao, Jingwei;  Zhu, Kongkai;  Du, Daohai;  Zhang, Yuanyuan;  Tao, Hongrui 收藏  |  浏览/下载：35/0  |  提交时间：2020/07/01 PRMT5 inhibitors  N-Substituted 1,2,3,4-tetrahydroisoquinoline derivatives  Anti-tumor   Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer 期刊论文 2019, 卷号: 7, 期号: 1, 页码: 198 作者:  Cai, Liangliang;  Bai, Hua;  Duan, Jianchun;  Wang, Zhijie;  Gao, Shugeng 收藏  |  浏览/下载：8/0  |  提交时间：2020/01/03 Genetics  Epigenetics  Non-small cell lung cancer  Tumor mutation burden  Checkpoint inhibitor therapy