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Synthesis and Biological Activities of Dihydrooxazolo[5,4-d]- pyrrolo[1,2-a]pyrimidinones
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 卷号: 42, 期号: 2, 页码: 543-556
作者:
Zeng, Y (Zeng Yan) [1] , [2]
;
Nie, LF (Nie Lifei) [1]
;
Niu, C (Niu Chao) [1]
;
Mamatjan, A (Mamatjan Aytilla) [1] , [2]
;
Bozorov, K (Bozorov Khurshed) [1]
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/05/17
oxazopyrimidinone
synthesis
bioisosterism
anticancer activity
antimicrobial activity
structure-activity relationships (SARs)
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
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  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Discovery and structure - activity relationship exploration of pyrazolo [1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 48, 页码: 13
作者:
Chen, Yun
;
Bai, Gang
;
Li, Yan
;
Ning, Yi
;
Cao, Sufen
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  |  
浏览/下载:32/0
  |  
提交时间:2021/12/01
FLT3
FLT3-ITD
Acute myeloid leukemia
Structure-activity relationships
Pyrazolo[1, 5-a]pyrimidine
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
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  |  
浏览/下载:187/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
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  |  
浏览/下载:111/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
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  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus(dagger)
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 3, 页码: 671-676
作者:
Yu, Chen-Xi
;
Wei, Bing-Yan
;
Kong, Xue-Qing
;
Yang, Cai-Guang
;
Nan, Fa-Jun
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  |  
浏览/下载:41/0
  |  
提交时间:2021/05/24
Bengamides
Staphylococcus aureus
Antibiotics
Structure‐
activity relationships
Pharmacokinetic
Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements
期刊论文
PHYTOCHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 88-91
作者:
Huguet, Clement
;
Real, Eleonore
;
Zhao, Wei-Min
;
Urbain, Aurelie
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  |  
浏览/下载:11/0
  |  
提交时间:2021/11/04
Pregnanes
Cynanchum
Apocynaceae
Diabetes
Glucagon-like peptide-1
Structure-activity relationships
Flavonoid compounds isolated from Tibetan herbs, binding to GABA(A) receptor with anxiolytic property
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 267
作者:
Liu, Zenggen
;
Silva, Joshua
;
Shao, Amy S.
;
Liang, Jing
;
Wallner, Martin
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  |  
浏览/下载:20/0
  |  
提交时间:2021/11/18
Flavonoids
Tibetan herbs
GABA(A) receptor
Structure-activity relationships
Anxiety
Bioassay-guided isolation of antioxidant, antimicrobial, and antiviral constituents of Cordia dichotoma fruits
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2021, 卷号: 172, 期号: 11, 页码: 1-12
作者:
Yaermaimaiti, S (Yaermaimaiti, Saimijiang) 1 , 2 , 3
;
Wu, T (Wu, Tao) 1 , 2
;
Aisa, HA (Aisa, Haji Akber) 1 , 2 , 3
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/12/06
Cordia dichotoma
Bioassay-guided isolation
Phenolics constituents
Structure-activity relationships
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