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Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Simulating androgen receptor selection in designer yeast
期刊论文
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022, 卷号: 7
作者:
Zhang, Haoran
;
Zhang, Lu
;
Xu, Yipeng
;
Chen, Shaoyong
;
Ma, Zhenyi
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  |  
浏览/下载:21/0
  |  
提交时间:2022/12/23
Androgen receptor mutations
Androgen receptor antagonists
Prostate cancer
Saccharomyces cerevisiae
Targeting KRAS mutant cancers: from druggable therapy to drug resistance
期刊论文
MOLECULAR CANCER, 2022, 卷号: 21
作者:
Zhu, Chunxiao
;
Guan, Xiaoqing
;
Zhang, Xinuo
;
Luan, Xin
;
Song, Zhengbo
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/12/23
KRAS mutations
Druggable
Resistance
Combination therapy
HER2 exon 20 insertion mutations in lung adenocarcinoma with leptomeningeal metastasis: a case report and response to poziotinib
期刊论文
ANNALS OF PALLIATIVE MEDICINE, 2022, 卷号: 11
作者:
Fan, Ying
;
Qin, Jing
;
Han, Na
;
Lu, Hongyang
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  |  
浏览/下载:16/0
  |  
提交时间:2022/12/23
Leptomeningeal metastasis (LM)
cerebrospinal fluid
HER2 exon 20 insertion mutations
poziotinib
case report
Early Domestication History of Asian Rice Revealed by Mutations and Genome-Wide Analysis of Gene Genealogies
期刊论文
RICE, 2022, 卷号: 15, 期号: 1
作者:
Lu, Yingqing
;
Xu, Yunzhang
;
Li, Nan
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  |  
浏览/下载:0/0
  |  
提交时间:2024/03/07
5 ' Genealogy
Coding genealogy
Early mutations
Positive selection
New alleles
Domestication genes
Domesticated traits
Gene type
Hybrid origin
Asian rice
DAGM: A novel modelling framework to assess the risk of HER2-negative breast cancer based on germline rare coding mutations
期刊论文
EBIOMEDICINE, 2021, 卷号: 69, 页码: 11
作者:
Yang, Mei
;
Fan, Yanhui
;
Wu, Zhi-Yong
;
Gu, Jin
;
Feng, Zhendong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/12/01
HER2-negative breast cancer
Germline rare coding mutations
Damage assessment of genomic mutations (DAGM)
Risk assessment
Activity profiles of signalling pathways (APSP)
HER2 signalling pathway
Immune suppression
Towards customized cancer vaccines: a promising filed in personalized cancer medicine
期刊论文
EXPERT REVIEW OF VACCINES, 2021
作者:
Xu, Xiaoling
;
Zhou, Zichao
;
Li, Hui
;
Fan, Yun
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/17
Cancer vaccines
tumor
neoantigens
personalized treatment
mutations
A collaborative LSHADE algorithm with comprehensive learning mechanism
期刊论文
Applied Soft Computing Journal, 2020, 卷号: 96
作者:
Zhao, Fuqing
;
Zhao, Lexi
;
Wang, Ling
;
Song, Houbin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/11/14
Covariance matrix
Benchmark functions
Comprehensive learning
Cooperative mechanisms
Cooperative mutations
Exploration and exploitation
Mutation operations
Optimization problems
State of the art
Network-based analysis with primary cells reveals drug response landscape of acute myeloid leukemia
期刊论文
EXPERIMENTAL CELL RESEARCH, 2020, 卷号: 393
作者:
Chen, Cheng
;
Wang, Li
;
Li, Lili
;
Wang, Aoli
;
Huang, Tao
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  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Acute myeloid leukemia (AML)
Drug response
Gene mutations
Two strategy cooperative particle swarm optimization algorithm with independent parameter adjustment and its application
期刊论文
International Journal of Innovative Computing, Information and Control, 2020, 卷号: 16, 期号: 4, 页码: 1203-1223
作者:
Zhang, Qiwen
;
Wei, Yachen
;
Song, Weiyang
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/11/14
Job shop scheduling
Learning algorithms
Parameter estimation
Convergence analysis
Cooperative particle swarm optimizations
Differential mutations
Exploitation and explorations
Flexible job-shop scheduling problem
Independent parameters
Pre-mature convergences
Standard test functions
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