Towards customized cancer vaccines: a promising filed in personalized cancer medicine

doi:10.1080/14760584.2021.1909479

	Towards customized cancer vaccines: a promising filed in personalized cancer medicine
	Xu, Xiaoling 1,2; Zhou, Zichao 1,3; Li, Hui 1,2; Fan, Yun 1,2
刊名	EXPERT REVIEW OF VACCINES
	2021-04-04
关键词	Cancer vaccines tumor neoantigens personalized treatment mutations
ISSN号	1476-0584
DOI	10.1080/14760584.2021.1909479
通讯作者	Fan, Yun(fanyun@zjcc.org.cn)
英文摘要	Introduction Cancer remains a major source of disease burden worldwide. Although cancer vaccines have been developed, most currently available cancer vaccines have limited therapeutic efficacy. Recent research using novel sequencing and bioinformatic tools has led scientists to realize that each tumor harbors a unique set of genetic mutations that can manifest as tumor-specific neoantigens. Therefore, it would be useful to develop personalized cancer vaccines that target neoantigens, which might improve the efficacy of these cancer treatments. Areas covered This review covers cancer vaccine development and the emerging field of personalized cancer vaccines, with a discussion of future clinical trials for this promising treatment strategy. Expert opinion Developing vaccines to treat tumors is one of the most promising and exciting fields in cancer research. However, cancer vaccines have shown limited efficacy in clinical trials for several decades, which may be related to the unique and complex processes underlying tumor development and progression. Recent studies have indicated that tumors express highly specific neoantigens, which are distinct from self-antigens. Thus, developing cancer vaccines that target these tumor-specific neoantigens is a promising strategy for developing personalized cancer vaccines.
资助项目	National Natural Science Foundation of China[81802995] ; Zhejiang Natural Science Foundation[LY16H160039] ; Zhejiang Province Public Welfare Funds[LGF19H280004] ; Medical Science and Technology Project of Zhejiang Province[2018RC020] ; Medical Science and Technology Project of Zhejiang Province[2018KY024]
WOS研究方向	Immunology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000636880500001
资助机构	National Natural Science Foundation of China ; Zhejiang Natural Science Foundation ; Zhejiang Province Public Welfare Funds ; Medical Science and Technology Project of Zhejiang Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121600]
专题	中国科学院合肥物质科学研究院
通讯作者	Fan, Yun
作者单位	1.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Surg, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Xu, Xiaoling,Zhou, Zichao,Li, Hui,et al. Towards customized cancer vaccines: a promising filed in personalized cancer medicine[J]. EXPERT REVIEW OF VACCINES,2021.
APA	Xu, Xiaoling,Zhou, Zichao,Li, Hui,&Fan, Yun.(2021).Towards customized cancer vaccines: a promising filed in personalized cancer medicine.EXPERT REVIEW OF VACCINES.
MLA	Xu, Xiaoling,et al."Towards customized cancer vaccines: a promising filed in personalized cancer medicine".EXPERT REVIEW OF VACCINES (2021).