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上海药物研究所 [32]
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期刊论文 [263]
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2019 [272]
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Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:93/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Effective Virtual Screening Strategy toward heme-containing proteins: Identification of novel IDO1 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 23
作者:
Zou, Yi
;
Hu, Yue
;
Ge, Shushan
;
Zheng, Yingbo
;
Li, Yuezhen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
IDO1
Heme
T cell
Cancer immunotherapy
Virtual screening
Drug design
Molecular dynamics simulation
Micromixers and their applications in kinetic analysis of biochemical reactions
期刊论文
TALANTA, 2019, 卷号: 205, 页码: 9
作者:
Liu, Chao
;
Li, Ying
;
Liu, Bi-Feng
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  |  
浏览/下载:332/0
  |  
提交时间:2019/12/06
Micromixer
Fast mixing
Kinetics
Protein folding
DNA/RNA folding
Biomolecular interaction
Enzyme catalysis
p38 MAPK is involved in the immune response to pathogenic Vibrio in the clam Meretrix petechialis
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 95, 页码: 456-463
作者:
Zhang, Shujing
;
Yu, Jiajia
;
Wang, Hongxia
;
Liu, Baozhong
;
Yue, Xin
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  |  
浏览/下载:25/0
  |  
提交时间:2020/03/20
p38 MAPK
Vibrio challenge
Immune defence
MITF
Adsorption of extracellular polymeric substances from two microbes by TiO2 nanoparticles
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 694, 页码: -
作者:
Gao, Xuan
;
Middepogu, Ayyaraju
;
Deng, Rui
;
Liu, Jingfu
;
Hao, Zhineng
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  |  
浏览/下载:19/0
  |  
提交时间:2020/09/10
Nanomaterial
Sorption
Bio-nano interaction
Algae
Bacteria
AZD9291 inactivates the PRC2 complex to mediate tumor growth inhibition
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1587-1595
作者:
Zhang, Kai-li
;
Shen, Qian-qian
;
Fang, Yan-fen
;
Sun, Yi-ming
;
Ding, Jian
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  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
PRC2
EZH2-EED
AZD9291
miR-34a
non-canonical base pairing
Targeting epigenetic machinery: Emerging novel allosteric inhibitors
期刊论文
PHARMACOLOGY & THERAPEUTICS, 2019, 卷号: 204, 页码: 24
作者:
Ye, Fei
;
Huang, Jing
;
Wang, Hongbo
;
Luo, Cheng
;
Zhao, Kehao
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Epigenetics
PRC2
MLL complex
SWI/SNF
DNMT1
allosteric inhibitors
Analysis of miRNA expression profiles in the liver of Clock(Delta 19) mutant mice
期刊论文
PEERJ, 2019, 卷号: 7, 页码: 19
作者:
Wang, Yanli
;
Lv, Ke
;
Zhao, Mei
;
Chen, Hailong
;
Ji, Guohua
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  |  
浏览/下载:13/0
  |  
提交时间:2020/02/29
Liver
Clock mutation
Circadian rhythms
miRNAs
Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies
期刊论文
PARTICLE AND FIBRE TOXICOLOGY, 2019, 卷号: 16, 期号: 1, 页码: -
作者:
Xu, Ming
;
Yang, Qiuyuan
;
Xu, Lining
;
Rao, Ziyu
;
Cao, Dong
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/09/10
Silver nanoparticles
Silver ion
Hepatotoxicity
Protein target
Glutathione S-transferase
Comparative iTRAQ proteomics revealed proteins associated with lobed fin regeneration in Bichirs
期刊论文
Proteome Science, 2019, 卷号: 17, 期号: 1, 页码: 1-10
作者:
Lu,Suxiang
;
Xiong,Qian
;
Du,Kang
;
Gan,Xiaoni
;
Wang,Xuzhen
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  |  
浏览/下载:285/0
  |  
提交时间:2019/12/04
Quantitative proteome
Polypterus senegalus
Limb
Regrowth
Blastema
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