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上海药物研究所 [67]
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期刊论文 [297]
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2017 [312]
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Discovery and development of pyrotinib: A novel irreversible EGFR/HER2 dual tyrosine kinase inhibitor with favorable safety profiles for the treatment of breast cancer
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 卷号: 110, 页码: 51-61
作者:
Li, Xin
;
Yang, Changyong
;
Wan, Hong
;
Zhang, Ge
;
Feng, Jun
收藏
  |  
浏览/下载:136/0
  |  
提交时间:2019/01/08
Pyrotinib
HER2-postive breast cancer
Irreversible EGFR/HER2 dual tyrosine kinase
inhibitor
Preclinical
Clinical
Safety
Drug metabolism
Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones
期刊论文
SCIENTIFIC REPORTS, 2017, 卷号: 7
作者:
Xu, Shan
;
Zhou, Yanping
;
Geng, Hui
;
Song, Dandan
;
Tang, Jing
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  |  
浏览/下载:30/0
  |  
提交时间:2018/11/05
Pharmacologic characterization of SHR8443, a novel dual inhibitor of phosphatidylinositol 3-kinase and mammalian target of rapamycin
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 64, 页码: 107977-107990
作者:
Xie, Chengying
;
Chen, Xiangling
;
Zheng, Mingyue
;
Liu, Xiaohong
;
Wang, Hongbin
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
BEZ235
drug resistance
mTOR
PI3K
SHR8443
Genomic insights into the pathogenicity and environmental adaptability of Enterococcus hirae R17 isolated from pork offered for retail sale
期刊论文
MICROBIOLOGYOPEN, 2017, 卷号: 6, 期号: 6, 页码: 15
作者:
Peng, Zixin
;
Li, Menghan
;
Wang, Wei
;
Liu, Hongtao
;
Fanning, Seamus
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  |  
浏览/下载:42/0
  |  
提交时间:2019/05/30
drug-resistance gene
Enterococcus hirae
genomic island
genomic plasticity
mobile genetic element
virulence gene
Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from justicia glauca against oral pathogens: a nanoantibiotic approach
期刊论文
Microbial pathogenesis, 2017, 卷号: 113, 页码: 295-302
作者:
Emmanuel, Rayappan
;
Saravanan, Muthupandian
;
Ovais, Muhammad
;
Padmavathy, Sethuramasamy
;
Shinwari, Zabta Khan
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  |  
浏览/下载:64/0
  |  
提交时间:2019/04/23
Green synthesis
Gold nanoparticles
Justicia glauca
Antimicrobial activity
Oral pathogens
Biosynthesized colloidal silver and gold nanoparticles as emerging leishmanicidal agents: an insight
期刊论文
Nanomedicine, 2017, 卷号: 12, 期号: 24, 页码: 2807-2819
作者:
Ovais, Muhammad
;
Nadhman, Akhtar
;
Khalil, Ali Talha
;
Raza, Abida
;
Khuda, Fazli
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2019/04/23
Green synthesis
Leishmaniasis
Nanomedicine
Phyto-nanotechnology
Silver and gold nanoparticles
Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry
期刊论文
Inorganic chemistry communications, 2017, 卷号: 86, 页码: 82-86
作者:
Zheng, Yuchuan
;
Xi, Zhaoyong
;
Li, Chan
;
Yuan, Siming
;
Li, Changjiang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/04/23
Platinum
Antitumor
Protein
Hydrolysis
Hypoxia induces universal but differential drug resistance and impairs anticancer mechanisms of 5-fluorouracil in hepatoma cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 12, 页码: 1642-1654
作者:
Li, Jing-qiu
;
Wu, Xian
;
Gan, Lu
;
Yang, Xiang-liang
;
Miao, Ze-hong
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
hepatocellular carcinoma
hypoxia
5-fluorouracil
sorafenib
drug resistance
An ultrasensitive fluorogenic probe for revealing the role of glutathione in chemotherapy resistance
期刊论文
CHEMICAL SCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 8012-8018
作者:
Jiang, Yuejing
;
Cheng, Juan
;
Yang, Chengyu
;
Hu, Yongzhou
;
Li, Jia
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Reprogramming Tumor-Associated Macrophages To Reverse EGFR(T790M) Resistance by Dual-Targeting Codelivery of Gefitinib/Vorinostat
期刊论文
NANO LETTERS, 2017, 卷号: 17, 期号: 12, 页码: 7684-7690
作者:
Peng, Huige
;
Chen, Binfan
;
Huang, Wei
;
Tang, Yubo
;
Jiang, Yifan
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/01/08
Tumor-associated macrophages
gefitinib
vorinostat
EGFR(T790M)
nonsmall cell lung cancer
drug resistance
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