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	Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from justicia glauca against oral pathogens: a nanoantibiotic approach
	Emmanuel, Rayappan1; Saravanan, Muthupandian2; Ovais, Muhammad3,4; Padmavathy, Sethuramasamy5; Shinwari, Zabta Khan3; Prakash, Periyakaruppan1
刊名	Microbial pathogenesis
	2017-12-01
卷号	113页码:295-302
关键词	Green synthesis Gold nanoparticles Justicia glauca Antimicrobial activity Oral pathogens
ISSN号	0882-4010
DOI	10.1016/j.micpath.2017.10.055
通讯作者	Saravanan, muthupandian(bioinfosaran@gmail.com) ; Prakash, periyakaruppan(kmpprakash@gmail.com)
英文摘要	Antimicrobial resistance is a challenging task for researchers to develop new strategies. green synthesis of aunps is an eco-friendly approach, which can be utilized in the microbistatic and microbicidal activities. the current study is focused on justicia glauca (aqueous leaf extract) mediated aunps synthesis at room temperature by treating chloroaurate ions, that shows an antagonistic effect with azithromycin (azm) and clarithromycin (clr) antibiotics against oral pathogenic bacteria and fungi (micrococcus luteus, bacillus subtilis, staphylococcus aureus, streptococcus mutans, lactobacillus acidophilus, escherichia colt, pseudomonas aeruginosa, saccharomyces cerevisiae and candida albicans). characterization of green synthesized aunps was done by using ultraviolet-visible (uvvis) spectroscopy, fourier transform infrared (ftir) spectroscopy, transmission electron microscopy (tem), x ray diffraction (xrd) analysis and energy dispersive x-ray analysis (edax). biosynthesized aunps were stable, hexagonal and spherical shaped with a size similar to 32.5 +/- 0.25 nm. the aunps and drug conjugated aunps showed potential antibacterial and antifungal activity against the oral pathogens. minimum inhibitory concentration (mic) values of biogenic aunps were observed in the range of 6.25-25 mu g/ml against selected oral pathogens. overall, we conclude that biogenic drug delivery system for azm and clr can be exploited as potential antimicrobial therapy in future, subject to detailed in-vitro and in-vivo cytotoxicity.
WOS关键词	SILVER NANOPARTICLES ; GREEN SYNTHESIS ; ANTIBACTERIAL EFFICACY ; METALLIC NANOPARTICLES ; AGENTS ; BACTERIA ; ANTIBIOTICS ; NANOSHELLS ; PROCUMBENS ; DELIVERY
WOS研究方向	Immunology ; Microbiology
WOS类目	Immunology ; Microbiology
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000418631900042
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177814
专题	高能物理研究所
通讯作者	Saravanan, Muthupandian; Prakash, Periyakaruppan
作者单位	1.Thiagarajar Coll Engn, Post Grad & Res Dept Chem, Madurai 625009, Tamil Nadu, India 2.Mekelle Univ, Coll Hlth Sci, Inst Biomed Sci, Dept Med Microbiol & Immunol, Mekelle 1871, Ethiopia 3.Quaid I Azam Univ, Dept Biotechnol, Islamabad 45320, Pakistan 4.Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 5.Thiagarajar Coll Engn, Dept Zool & Microbiol, Madurai 625009, Tamil Nadu, India
推荐引用方式 GB/T 7714	Emmanuel, Rayappan,Saravanan, Muthupandian,Ovais, Muhammad,et al. Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from justicia glauca against oral pathogens: a nanoantibiotic approach[J]. Microbial pathogenesis,2017,113:295-302.
APA	Emmanuel, Rayappan,Saravanan, Muthupandian,Ovais, Muhammad,Padmavathy, Sethuramasamy,Shinwari, Zabta Khan,&Prakash, Periyakaruppan.(2017).Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from justicia glauca against oral pathogens: a nanoantibiotic approach.Microbial pathogenesis,113,295-302.
MLA	Emmanuel, Rayappan,et al."Antimicrobial efficacy of drug blended biosynthesized colloidal gold nanoparticles from justicia glauca against oral pathogens: a nanoantibiotic approach".Microbial pathogenesis 113(2017):295-302.

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