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	Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry
	Zheng, Yuchuan1; Xi, Zhaoyong2; Li, Chan3; Yuan, Siming2; Li, Changjiang1; Liu, Yangzhong2
刊名	Inorganic chemistry communications
	2017-12-01
卷号	86页码:82-86
关键词	Platinum Antitumor Protein Hydrolysis
ISSN号	1387-7003
DOI	10.1016/j.inoche.2017.09.030
通讯作者	Zheng, yuchuan(zhengyc@hsu.edu.cn)
英文摘要	Increasing evidence indicates that the copper chaperone atox1 involves the mechanism of pt-drugs. here, the interactions of atox1 with cisplatin and cisplatin analogues were studied. results show that, like cisplatin, the other three pt complexes can interact with atox1 and cu-i coordination obviously enhances the platination of atox1. cisplatin, carboplatin and nedaplatin formed some of adducts with the same composition due to having the same cis-diammine carrier ligands and differ only in the leaving groups. nedaplatin, similar to carboplatin, was relatively inert with respect to cisplatin. remarkably, an unexpected adduct with loss' of the 1, 2-diaminocyclohexane (dach) carrier ligand were observed in the reaction of oxaliplatin with holo-atox1. these results indicate that both platination adducts and rates of platination are significantly influenced by the ligand and cuprous ion, suggesting the probably different influence of atox1 on pt-drugs in vivo. (c) 2017 elsevier b.v. all rights reserved.
WOS关键词	ANTICANCER DRUG CARBOPLATIN ; RESISTANCE ; BINDING ; PROMOTES ; ADDUCTS ; PROTEIN ; CANCER
WOS研究方向	Chemistry
WOS类目	Chemistry, Inorganic & Nuclear
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000418971600020
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/2177876
专题	高能物理研究所
通讯作者	Zheng, Yuchuan
作者单位	1.Huangshan Univ, Dept Chem, Huangshan 245041, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, CAS High Magnet Field Lab, Hefei 230026, Anhui, Peoples R China 3.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zheng, Yuchuan,Xi, Zhaoyong,Li, Chan,et al. Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry[J]. Inorganic chemistry communications,2017,86:82-86.
APA	Zheng, Yuchuan,Xi, Zhaoyong,Li, Chan,Yuan, Siming,Li, Changjiang,&Liu, Yangzhong.(2017).Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry.Inorganic chemistry communications,86,82-86.
MLA	Zheng, Yuchuan,et al."Interactions between human copper chaperone atox1 and cisplatin, carboplatin, nedaplatin and oxaliplatin studied by esi mass spectrometry".Inorganic chemistry communications 86(2017):82-86.

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