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期刊论文 [28]
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Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
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浏览/下载:70/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
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  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer's disease.
期刊论文
Bioorganic chemistry, 2019, 卷号: Vol.93, 页码: 103328
作者:
Rong Cai
;
Li-Ning Wang
;
Jing-Jing Fan
;
Shang-Qi Geng
;
Yu-Ming Liu
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  |  
浏览/下载:9/0
  |  
提交时间:2019/11/21
4-N-phenylaminoquinoline
Alzheimer’s disease
Anti-cholinesterase activity
Antioxidant
Metal chelator
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
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  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer's Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches
期刊论文
2017, 卷号: 22, 期号: 8
作者:
Pang, Xiaocong
;
Fu, Hui
;
Yang, Shilun
;
Wang, Lin
;
Liu, Ai-Lin
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  |  
浏览/下载:10/0
  |  
提交时间:2020/01/04
cholinesterase inhibitor
Alzheimer's disease
DL0410
3D-QSAR
molecular docking
kinetics
The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays
期刊论文
MOLECULAR BIOSYSTEMS, 2016, 卷号: 12, 期号: 12, 页码: 3734-3742
作者:
Zhang, Yunqin
;
Zhang, Shuqun
;
Xu, Guowei
;
Yan, Hui
;
Pua, Yinglan
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  |  
浏览/下载:29/0
  |  
提交时间:2017/02/14
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 4, 页码: 672-680
作者:
Luo, Wen[1]
;
Chen, Ying[2]
;
Wang, Ting[3]
;
Hong, Chen[4]
;
Chang, Li-Ping[5]
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
Flavonoid derivatives
Cholinesterase
Anti-Alzheimer agent
Molecular modeling
Cytotoxicity
Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 122, 页码: 17-26
作者:
Luo Wen[1]
;
Wang Ting[2]
;
Hong Chen[3]
;
Yang Ya-Chen[4]
;
Chen Ying[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Flavonoid
Anti-Alzheimer agent
Cholinesterase
A beta aggregation
Antioxidation
Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species
期刊论文
MOLECULES, 2015, 卷号: 20, 期号: 12, 页码: 21854-21869
作者:
Tian, Yongqiang
;
Zhang, Chunyun
;
Guo, Mingquan
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  |  
浏览/下载:11/0
  |  
提交时间:2017/04/13
Amaryllidaceae alkaloids
chemical fingerprints
chemical marker
anti-HepG2 activity
Fibroblast growth factor 21 protects mouse brain against D-galactose induced aging via suppression of oxidative stress response and advanced glycation end products formation
期刊论文
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2015, 卷号: 133, 期号: 0, 页码: 122-131
作者:
Yu, Yinhang
;
Bai, Fuliang
;
Wang, Wenfei
;
Liu, Yaonan
;
Yuan, Qingyan
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  |  
浏览/下载:46/0
  |  
提交时间:2015/09/08
FGF21
D-galactose
Aging
Oxidative stress
AGEs
Inflammation
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