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上海药物研究所 [16]
昆明植物研究所 [3]
河南大学 [3]
中国医学科学院 北京... [3]
兰州理工大学 [2]
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期刊论文 [28]
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Twin drug design, synthesis and evaluation of diosgenin derivatives as multitargeted agents for the treatment of vascular dementia
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 37, 页码: 16
作者:
Yang, Gui-Xiang
;
Sun, Jia-Min
;
Zheng, Lu-Lu
;
Zhang, Li
;
Li, Jie
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/06/11
Vascular dementia
Diosgenin
Antioxidant
Anti-cholinesterase
Multi-target-directed ligands
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
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  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
New 4-N-phenylaminoquinoline derivatives as antioxidant, metal chelating and cholinesterase inhibitors for Alzheimer's disease.
期刊论文
Bioorganic chemistry, 2019, 卷号: Vol.93, 页码: 103328
作者:
Rong Cai
;
Li-Ning Wang
;
Jing-Jing Fan
;
Shang-Qi Geng
;
Yu-Ming Liu
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  |  
浏览/下载:9/0
  |  
提交时间:2019/11/21
4-N-phenylaminoquinoline
Alzheimer’s disease
Anti-cholinesterase activity
Antioxidant
Metal chelator
Molecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors
期刊论文
Bioorganic chemistry, 2018, 卷号: 83, 页码: 277-288
作者:
Cheng, Zhi-Qiang
;
Zhu, Kong-Kai
;
Zhang, Juan
;
Song, Jia-Li
;
Muehlmann, Luis Alexandre
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  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer's Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches
期刊论文
2017, 卷号: 22, 期号: 8
作者:
Pang, Xiaocong
;
Fu, Hui
;
Yang, Shilun
;
Wang, Lin
;
Liu, Ai-Lin
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  |  
浏览/下载:10/0
  |  
提交时间:2020/01/04
cholinesterase inhibitor
Alzheimer's disease
DL0410
3D-QSAR
molecular docking
kinetics
The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays
期刊论文
MOLECULAR BIOSYSTEMS, 2016, 卷号: 12, 期号: 12, 页码: 3734-3742
作者:
Zhang, Yunqin
;
Zhang, Shuqun
;
Xu, Guowei
;
Yan, Hui
;
Pua, Yinglan
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  |  
浏览/下载:29/0
  |  
提交时间:2017/02/14
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 4, 页码: 672-680
作者:
Luo, Wen[1]
;
Chen, Ying[2]
;
Wang, Ting[3]
;
Hong, Chen[4]
;
Chang, Li-Ping[5]
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
Flavonoid derivatives
Cholinesterase
Anti-Alzheimer agent
Molecular modeling
Cytotoxicity
Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 122, 页码: 17-26
作者:
Luo Wen[1]
;
Wang Ting[2]
;
Hong Chen[3]
;
Yang Ya-Chen[4]
;
Chen Ying[5]
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
Flavonoid
Anti-Alzheimer agent
Cholinesterase
A beta aggregation
Antioxidation
Cholinesterase and Human Lung Cancer Cells (A-549) Inhibitory Activity of the Cassava Peel of Euphorbiaceae in Vitro
会议论文
Joint International Conference on Social Science and Environmental Science (SSES) / International Conference on Food Science and Engineering (ICFSE ), Guangzhou, PEOPLES R CHINA
作者:
Chen, Xiao-Ming
;
Zhang, Zhi-Jun
;
Liu, Ai-Lin
;
Lv, Fei-Jie
;
Li, Shu-Fang
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  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Cassava Peel
Extraction
AchE
BuChE
Inhibitory Activity
Anti-tumor
A-549
Cholinesterase and Human Lung Cancer Cells (A-549) Inhibitory Activity of the Cassava Peel of Euphorbiaceae in Vitro
会议论文
JOINT 2016 INTERNATIONAL CONFERENCE ON SOCIAL SCIENCE AND ENVIRONMENTAL SCIENCE (SSES 2016) AND INTERNATIONAL CONFERENCE ON FOOD SCIENCE AND ENGINEERING (ICFSE 2016), 2016-01-01
作者:
Chen, Xiao-Ming
;
Zhang, Zhi-Jun
;
Liu, Ai-Lin
;
Lv, Fei-Jie
;
Li, Shu-Fang
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/01/04
Cassava Peel
Extraction
AchE
BuChE
Inhibitory Activity
Anti-tumor
A-549
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