Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species

doi:10.3390/molecules201219806

CORC > 武汉植物园 > 中国科学院武汉植物园

	Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species
	Tian, Yongqiang 1,2; Zhang, Chunyun 1; Guo, Mingquan 1
刊名	MOLECULES
	2015-12-01
卷号	20 期号:12 页码:21854-21869
关键词	Amaryllidaceae alkaloids chemical fingerprints chemical marker anti-HepG2 activity
ISSN号	1420-3049
DOI	10.3390/molecules201219806
英文摘要	The major active constituents from Amaryllidaceae family were reported to be Amaryllidaceae alkaloids (AAs), which exhibited a wide spectrum of biological activities, such as anti-tumor, anti-viral, and acetyl-cholinesterase-inhibitory activities. In order to better understand their potential as a source of bioactive AAs and the phytochemical variations among three different species of Lycoris herbs, the HPLC fingerprint profiles of Lycorisaurea (L. aurea), L. radiata, and L. guangxiensis were firstly determined and compared using LC-UV and LC-MS/MS. As a result, 39 peaks were resolved and identified as AAs, of which nine peaks were found in common for all these three species, while the other 30 peaks could be revealed as characteristic AAs for L. aurea, L. radiata and L. guangxiensis, respectively. Thus, these AAs can be used as chemical markers for the identification and quality control of these plant species. To further reveal correlations between chemical components and their pharmaceutical activities of these species at the molecular level, the bioactivities of the total AAs from the three plant species were also tested against HepG2 cells with the inhibitory rate at 78.02%, 84.91% and 66.81% for L. aurea, L. radiata and L. guangxiensis, respectively. This study firstly revealed that the three species under investigation were different not only in the types of AAs, but also in their contents, and both contributed to their pharmacological distinctions. To the best of our knowledge, the current research provides the most detailed phytochemical profiles of AAs in these species, and offers valuable information for future valuation and exploitation of these medicinal plants.
资助项目	"Hundred Talents Program" from Chinese Academy of Sciences[29Y429291a0129] ; Sino-Africa joint research project[SAJC201328]
WOS研究方向	Chemistry
语种	英语
出版者	MDPI AG
WOS记录号	WOS:000367533400064
内容类型	期刊论文
源URL	[http://202.127.146.157/handle/2RYDP1HH/169]
专题	中国科学院武汉植物园
通讯作者	Guo, Mingquan
作者单位	1.Chinese Acad Sci, Sino Africa Joint Res Ctr, Key Lab Plant Germplasm Enhancement & Specialty A, Wuhan Bot Garden, Wuhan 430074, Peoples R China 2.Grad Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tian, Yongqiang,Zhang, Chunyun,Guo, Mingquan. Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species[J]. MOLECULES,2015,20(12):21854-21869.
APA	Tian, Yongqiang,Zhang, Chunyun,&Guo, Mingquan.(2015).Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species.MOLECULES,20(12),21854-21869.
MLA	Tian, Yongqiang,et al."Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species".MOLECULES 20.12(2015):21854-21869.