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Systematic review and meta-analysis of prevalence of dermatological toxicities associated with vemurafenib treatment in patients with melanoma
期刊论文
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2019, 卷号: 44, 期号: 3
作者:
Chen, P.
;
Chen, F.
;
Zhou, B.
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 93, 期号: 2, 页码: 177-187
作者:
Niu, Yuzhen
;
Zhang, Yan
;
Yao, Xiaojun
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
binding free energy calculation
BRAF inhibitors
drug resistance
molecular dynamics simulation
residue interaction network analysis
Signal transducer and activator of transcription 3 inhibition enhances vemurafenib sensitivity in colon cancers harboring the BRAF mutation
期刊论文
Journal of Cellular Biochemistry, 2019, 卷号: Vol.120 No.4, 页码: 5315-5325
作者:
Kai Wang
;
Yanrong Li
;
Na Song
;
Xiaofang Che
;
Kezuo Hou
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
apoptosis
colon
cancer
proliferation
signal
transducer
and
activator
of
transcription
3
vemurafenib
Acquired and intrinsic resistance to vemurafenib in BRAF(v600e)-driven melanoma brain metastases
会议论文
Annual Meeting of the American-Association-for-Cancer-Research (AACR), MAR 29-APR 03, 2019
作者:
de Gooijer, Mark C.
;
Zhang, Ping
;
Buil, Levi C.
;
Freriks, Stephan
;
Li, Gang
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/31
Rafoxanide, an organohalogen drug, triggers apoptosis and cell cycle arrest in multiple myeloma by enhancing DNA damage responses and suppressing the p38 MAPK pathway
期刊论文
Cancer letters, 2018, 卷号: 444, 页码: 45-59
作者:
Xiao, Wenqin
;
Xu, Zhijian
;
Chang, Shuaikang
;
Li, Bo
;
Yu, Dandan
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  |  
浏览/下载:98/0
  |  
提交时间:2019/01/08
Identification of recurrent USP48 and BRAF mutations in Cushing's disease
期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9
作者:
Chen, Jianhua
;
Jian, Xuemin
;
Deng, Siyu
;
Ma, Zengyi
;
Shou, Xuefei
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  |  
浏览/下载:117/0
  |  
提交时间:2019/01/08
Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAFV600E mutations.
期刊论文
Oncol Lett, 2018, 卷号: Vol.15 No.3, 页码: 3904-3910
作者:
Zhi J
;
Li Z
;
Lv J
;
Feng B
;
Yang D
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  |  
浏览/下载:4/0
  |  
提交时间:2019/03/26
BRAF
PHA-665752
c-Met
colorectal
cancer
vemurafenib
Identification of recurrent USP48 and BRAF mutations in Cushing's disease
期刊论文
NATURE COMMUNICATIONS, 2018, 卷号: 9, 期号: 1, 页码: 3171
作者:
Chen, Jianhua
;
Jian, Xuemin
;
Song, Zhijian
;
Li, Zhiqiang
;
Zhou, Juan
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  |  
浏览/下载:74/0
  |  
提交时间:2019/04/28
Human Cancer
Proopiomelanocortin Gene
Deubiquitinating Enzyme
Pituitary-adenomas
Kappa-b
Transcription
Activation
Raf
Pathways
Genome
The BET-bromodomain inhibitor JQ1 mitigates vemurafenib drug resistance in melanoma
期刊论文
MELANOMA RESEARCH, 2018, 卷号: 28, 期号: 6, 页码: 521-526
作者:
Zhao, Bei
;
Cheng, Xiankui
;
Zhou, Xiyuan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/11
BET inhibitor
BRAF inhibitor
cancer drug resistance
melanoma
Docking-based structural splicing and reassembly strategy to develop novel deazapurine derivatives as potent B-Raf(V600E) inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1059-1068
作者:
Wang, Gui-min
;
Wang, Xiang
;
Zhu, Jian-ming
;
Guo, Bin-bin
;
Yang, Zhuo
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
B-Raf(V600E) inhibitor
anticancer
vemurafenib
deazapurine
fragment reassembly
molecular docking
structure-activity relationship
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