Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations | |
Niu, Yuzhen; Zhang, Yan; Yao, Xiaojun | |
刊名 | CHEMICAL BIOLOGY & DRUG DESIGN |
2019 | |
卷号 | 93期号:2页码:177-187 |
关键词 | binding free energy calculation BRAF inhibitors drug resistance molecular dynamics simulation residue interaction network analysis |
DOI | 10.1111/cbdd.13399 |
URL标识 | 查看原文 |
公开日期 | [db:dc_date_available] |
内容类型 | 期刊论文 |
URI标识 | http://www.corc.org.cn/handle/1471x/4538938 |
专题 | 山东大学 |
作者单位 | 1.Shandong Univ Technol, Sch Life Sci, Shandong Prov Res Ctr Bioinformat Engn & Tech, Zibo, Peoples R China. 2.Guiyang Coll |
推荐引用方式 GB/T 7714 | Niu, Yuzhen,Zhang, Yan,Yao, Xiaojun. Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2019,93(2):177-187. |
APA | Niu, Yuzhen,Zhang, Yan,&Yao, Xiaojun.(2019).Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations.CHEMICAL BIOLOGY & DRUG DESIGN,93(2),177-187. |
MLA | Niu, Yuzhen,et al."Resistance mechanism of the oncogenic beta 3-alpha C deletion mutation in BRAF kinase to dabrafenib and vemurafenib revealed by molecular dynamics simulations and binding free energy calculations".CHEMICAL BIOLOGY & DRUG DESIGN 93.2(2019):177-187. |
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