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科研机构
上海药物研究所 [6]
昆明动物研究所 [2]
水生生物研究所 [1]
合肥物质科学研究院 [1]
近代物理研究所 [1]
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期刊论文 [11]
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2021 [2]
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Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
;
Zhang, Yanan
;
Lv, Pei
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Discovery of Potent and Orally Bioavailable GPR40 Full Agonists Bearing Thiophen-2-ylpropanoic Acid Scaffold
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 7, 页码: 2697-2717
作者:
Li, He
;
Huang, Qi
;
Chen, Cheng
;
Xu, Bin
;
Wang, He-Yao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D-1, D-2 and serotonin 5-HT1A multi-action profile
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 4, 页码: 856-868
作者:
Sun, Haifeng
;
Zhu, Liyuan
;
Yang, Huicui
;
Qian, Wangke
;
Guo, Lin
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  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
Asymmetric synthesis
Tetrahydroprotoberberines
Dopamine receptors
Serotonin receptors
Multi-action
New pharmacological profile
Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1A Receptor Agonist
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2010, 卷号: 53, 期号: 3, 页码: 1319-1328
作者:
Liu, Zhili
;
Zhang, Hai
;
Ye, Na
;
Zhang, Jing
;
Wu, QianQian
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Pharmacological Characterization of ATPM [(-)-3-Amino-thiazolo[5,4-b]-N-cyclopropylmethylmorphinan hydrochloride], a Novel Mixed kappa-Agonist and mu-Agonist/-Antagonist That Attenuates Morphine Antinociceptive Tolerance and Heroin Self-Administration Behavior
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 卷号: 329, 期号: 1, 页码: 306-313
作者:
Wang, Yu-Jun
;
Tao, Yi-Min
;
Li, Fu-Ying
;
Wang, Yu-Hua
;
Xu, Xue-Jun
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Effects of adrenergic agonists on the extrahepatic expression of vitellogenin Ao1 in heart and brain of the Chinese rare minnow (Gobiocypris rarus)
期刊论文
AQUATIC TOXICOLOGY, 2009, 卷号: 91, 期号: 1, 页码: 19-25
作者:
Ma, Liwen
;
Li, Dongliang
;
Wang, Jianwei
;
He, Jiangyan
;
Yin, Zhan
收藏
  |  
浏览/下载:106/9
  |  
提交时间:2010/10/13
Chinese rare minnow
vtgAo1
Adrenergic agonist
Heart
Liver
Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: Virtual screening, synthesis, and biological evaluation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 卷号: 18, 期号: 20, 页码: 5497-5502
作者:
Deng, Guanghui
;
Li, Weihua
;
Shen, Jianhua
;
Jiang, Hualiang
;
Chen, Kaixian
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
farnesoid X receptor
pyrazolidine-3,5-dione
virtual screening
Recent advances towards the discovery of dopamine receptor ligands
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2006, 卷号: 16, 期号: 5, 页码: 587-630
作者:
Zhang, Ao
;
Kan, Ying
;
Li, Fuying
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
atypical antipsychotic
brain disorder
CNS
dopamine
dopamine agonist
dopamine antagonist
dopamine receptor
Parkinson's disease
schizophrenia
serotonin
Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1997, 卷号: 283, 期号: 1, 页码: 183-189
作者:
Cai JX
;
Arnsten AFT
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  |  
浏览/下载:9/0
  |  
提交时间:2010/08/24
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