Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys

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	Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys
	Cai JX 1; Arnsten AFT 2
刊名	JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
	1997
卷号	283 期号:1 页码:183-189
ISSN号	0022-3565
英文摘要	With advancing age, monkeys develop deficits in spatial working memory resembling those induced by lesions of the prefrontal cortex (PFC). Aged monkeys also exhibit marked loss of dopamine from the PFC, a transmitter known to be important for proper PFC cognitive function. Previous results suggest that D1 agonist treatment can improve spatial working memory abilities in aged monkeys. However, this research was limited by the use of drugs with either partial agonist actions or significant D2 receptor actions. In our study, the selective dopamine D1 receptor full agonists A77636 and SKF81297 were examined in aged monkeys for effects on the working memory functions of the PFC. Both compounds produced a significant, dose-related effect on delayed response performance without evidence of side effects: low doses improved performance although higher doses impaired or had no effect on performance. Both the improvement and impairment in performance were reversed by pretreatment with the D1 receptor antagonist, SCH23390. These findings are consistent with previous results demonstrating that there is a narrow range of D1 receptor stimulation for optimal PFC cognitive function, and suggest that very low doses of D1 receptor agonists may have cognitive-enhancing actions in the elderly.
收录类别	SCI
资助信息	This work was supported by The Chinese Academy of Sciences KP-85, KY-85 and NSFC to J.X.C. and Public Health Service Grant AG06036 to A.F.T.A.
原文出处	1997283183.pdf
语种	英语
公开日期	2010-08-24
内容类型	期刊论文
源URL	[http://159.226.149.42:8088/handle/152453/5125]
专题	昆明动物研究所_其他
作者单位	1.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan, China 650223 2.Section of Neurobiology, Yale Medical School, New Haven, Connecticut
推荐引用方式 GB/T 7714	Cai JX,Arnsten AFT. Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,1997,283(1):183-189.
APA	Cai JX,&Arnsten AFT.(1997).Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS,283(1),183-189.
MLA	Cai JX,et al."Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys".JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 283.1(1997):183-189.