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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Tailored nanodisc immobilization for one-step purification and reconstitution of cytochrome P450: A tool for membrane proteins' hard cases
期刊论文
JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 12
作者:
Zhao, Lan
;
Tao, Jiaoli
;
Huang, Yongdong
;
Zhu, Kai
;
Du, Yuxiang
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  |  
浏览/下载:59/0
  |  
提交时间:2021/08/31
cytochrome P450
membrane protein purification
nanodiscs
nanodisc-immobilized chromatography
reconstitution
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:45/0
  |  
提交时间:2020/07/01
Establishment of rat liver microsome-hydrogel system for in vitro phase II metabolism and its application to study pharmacological effects of UGT substrates
期刊论文
DRUG METABOLISM AND PHARMACOKINETICS, 2019, 卷号: 34, 期号: 2
作者:
Zhang, Zhe
;
Ma, Guo
;
Xue, Caifu
;
Sun, Hong
;
Wang, Ziteng
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  |  
浏览/下载:18/0
  |  
提交时间:2019/12/05
UGT
Phase II metabolism
FAB hydrogel
Liver microsome
Baicalein
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties
期刊论文
Investigational New Drugs, 2019
作者:
Wu J.-D.
;
Cui Y.-J.
;
Zhou Y.-G.
;
Tang L.-Q.
;
Zhang C.-M.
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/11
Hepatocellular carcinoma
Liver microsome stability
Multidrug-resistance
Pharmacokinetics
Tubulin polymerization inhibitor
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
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浏览/下载:234/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204
作者:
Li, Daqiang
;
Zhang, Xiaotuan
;
Ma, Xiaodong
;
Xu, Lei
;
Yu, Jianjun
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浏览/下载:30/0
  |  
提交时间:2019/01/08
Strategy for Hepatotoxicity Prediction Induced by Drug Reactive Metabolites Using Human Liver Microsome and Online 2D-Nano-LC-MS Analysis
期刊论文
ANALYTICAL CHEMISTRY, 2017, 卷号: 89, 期号: 24, 页码: 13167-13175
作者:
Zhuo, Yue
;
Wu, Jian-Lin
;
Yan, Xiaojing
;
Guo, Ming-Quan
;
Liu, Ning
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  |  
浏览/下载:85/0
  |  
提交时间:2017/12/31
Discovery of a widespread metabolic pathway within and among phenolic xenobiotics
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Ashrap, Pahriya
;
Zheng, Guomao
;
Wan, Yi
;
Li, Tong
;
Hu, Wenxin
;
Li, Wenjuan
;
Zhang, Hong
;
Zhang, Zhaobin
;
Hu, Jianying
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  |  
浏览/下载:32/0
  |  
提交时间:2017/12/03
triclosan
phenolic xenobiotic
liver microsome
metabolic kinetics
cross-talk reaction
CONSTITUTIVE ANDROSTANE RECEPTOR
REGULATING TRICLOSAN
UNITED-STATES
BISPHENOL-A
METHYL TRICLOSAN
CYTOCHROMES P450
ENZYMES
LIVER
TRICLOCARBAN
INDUCTION
Characterization of major metabolites of polymethoxylated flavonoids in Pericarpium Citri Reticulatae using liver microsomes immobilized on magnetic nanoparticles coupled with UPLC/MS-MS
期刊论文
CHEMISTRY CENTRAL JOURNAL, 2017, 卷号: 11, 页码: 13(1-10)
作者:
Liu, YM
;
Lei, J
;
Liao, X (reprint author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China.
;
Liao, X
;
Xue, Y
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  |  
浏览/下载:12/0
  |  
提交时间:2018/08/28
Liver Microsome
Magnetic Nanoparticles
Metabolism
Polymethoxylated Flavonoids
Pericarpium Citri Reticulatae
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