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上海药物研究所 [48]
山东大学 [14]
昆明动物研究所 [14]
北京大学 [8]
大连化学物理研究所 [4]
昆明植物研究所 [4]
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Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
期刊论文
NUCLEIC ACIDS RESEARCH, 2020, 卷号: 48, 期号: 5, 页码: 2709-2722
作者:
Nguyen, Phuong D. M.
;
Zheng, Jie
;
Gremminger, Thomas J.
;
Qiu, Liming
;
Zhang, Dong
收藏
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浏览/下载:20/0
  |  
提交时间:2020/07/01
Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H, 3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 17, 页码: 3836-3845
作者:
Gao, Ping
;
Cheng, Xiqiang
;
Sun, Lin
;
Song, Shu
;
Alvarez, Mar
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
HIV-1
RNase H
Integrase
Dual inhibitors
A new class of HIV-1 inhibitors and the target identification via proteomic profiling
期刊论文
SCIENCE CHINA-CHEMISTRY, 2018, 卷号: 61, 期号: 11, 页码: 1430-1439
作者:
Ge, Ying-Zi
;
Zhou, Bin
;
Xiao, Ruo-Xuan
;
Yuan, Xiao-Jing
;
Zhou, Hu
收藏
  |  
浏览/下载:183/0
  |  
提交时间:2019/01/08
ergostane-type steroids
anti-HIV
target identification
PKM2
Pr-957, a selective immunoproteasome inhibitor, reactivates latent hiv-1 through p-tefb activation mediated by hsf-1
期刊论文
Biochemical pharmacology, 2018, 卷号: 156, 页码: 511-523
作者:
Lin, Jian
;
Zhang, Xuanxuan
;
Lu, Wanzhen
;
Xu, Xinfeng
;
Pan, Xiaoyan
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  |  
浏览/下载:62/0
  |  
提交时间:2019/05/08
Hiv-1 latency
Lras
Pr-957
P-tefb
Heat shock factor 1
HAART in HIV/AIDS Treatments: Future Trends
期刊论文
Infectious disorders drug targets, 2018, 卷号: 18, 页码: 15-22
作者:
Lu Da-Yong[1]
;
Wu Hong-Ying[2]
;
Yarla Nagendra Sastry[3]
;
Xu Bin[4]
;
Ding Jian[5]
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/04/22
HAART
HIV cure
HIV latency
HIV reservoirs
antiviral therapy
biotherapy
drug delivery system
integrase inhibitors
medicinal chemistry
pharmacogenomics
5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155, 页码: 714-724
作者:
Sun, Lin
;
Gao, Ping
;
Dong, Guanyu
;
Zhang, Xujie
;
Cheng, Xiqiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
HAART
HIV-1 dual inhibitors
HIV-1 IN
RNase H
5-hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives
Privileged
structure
Synthesis, biological evaluation and molecular modeling of 2-Hydroxyisoquinoline-1,3-dione analogues as inhibitors of HIV reverse transcriptase associated ribonuclease H and polymerase
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 133, 页码: 85-96
作者:
Tang, Jing
;
Vernekar, Sanjeev Kumar V.
;
Chen, Yue-Lei
;
Miller, Lena
;
Huber, Andrew D.
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
2-hydroxyisoquinoline-1,3-diones
HIV
RNase H
Reverse transcriptase
Inhibitor
Discovery of novel 3-hydroxypicolinamides as selective inhibitors of HIV-1 integrase-LEDGF/p75 interaction
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1051-1063
作者:
Zhang, Feng-Hua
;
Debnath, Bikash
;
Xu, Zhong-Liang
;
Yang, Liu-Meng
;
Song, Li-Rui
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
HIV-1 integrase
Allosteric inhibitor
LEDGF/p75
Dimerization
3-Hydroxypicolinamide
Latest advances in the efficacy, tolerability, and monotherapy of integrase inhibitors
期刊论文
BIOSCIENCE TRENDS, 2017, 卷号: 11, 期号: 4
作者:
Tang, Qi
;
Lu, Hongzhou
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Dolutegravir
drug resistance
monotherapy
antiretroviral therapy
Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1
期刊论文
EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 卷号: 27, 期号: 11, 页码: 1277-1286
作者:
Cheng, Xiqiang
;
Gao, Ping
;
Sun, Lin
;
Tian, Ye
;
Zhan, Peng
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/12
AIDS
HIV-1
IN inhibitors
prodrug
privileged structure
drug design
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