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上海药物研究所 [51]
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复旦大学上海医学院 [5]
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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 220, 页码: 18
作者:
Xu, Dandan
;
Sun, Deqiao
;
Wang, Wei
;
Peng, Xia
;
Zhan, Zhengsheng
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2021/08/17
Axl
Cancer
Inhibitor
Pyrrolo[2,3-d]pyrimidine
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency
SHR-A1403, a novel c-mesenchymal-epithelial transition factor (c-Met) antibody-drug conjugate, overcomes AZD9291 resistance in non-small cell lung cancer cells overexpressing c-Met
期刊论文
CANCER SCIENCE, 2019, 页码: 11
作者:
Tong, Mengya
;
Gao, Mingzhao
;
Xu, Yongping
;
Fu, Li
;
Li, Yun
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
AZD9291
c-Met ADC
c-Met overexpression
resistance
SHR-A1403
Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 3, 页码: 2977-2984
作者:
Wang, Hui-Li
;
Liu, Yan-Chun
;
Long, Ming-Peng
;
Zheng, Chuan
;
Yang, Jia-Hui
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  |  
浏览/下载:95/0
  |  
提交时间:2019/11/07
receptor tyrosine kinase-like orphan receptor 1
lung adenocarcinoma
erlotinib resistance
AKT
mammalian target of rapamycin
small interfering RNA
SHR-A1403, a novel c-Met antibody-drug conjugate, exerts encouraging anti-tumor activity in c-Met-overexpressing models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 7, 页码: 971-979
作者:
Yang, Chang-yong
;
Wang, Lei
;
Sun, Xing
;
Tang, Mi
;
Quan, Hai-tian
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
SHR-A1403
c-Met ADC
anti-tumor
patient-derived xenograft (PDX)
molecular mechanisms
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1
期刊论文
GASTROENTEROLOGY, 2019, 卷号: 156, 期号: 6
作者:
Li, Hui
;
Li, Chia-Wei
;
Li, Xiaoqiang
;
Din, Qingqing
;
Guo, Lei
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/05
Programmed Cell Death Ligand 1
Hepatocellular Carcinoma
Tumor Necrosis Factor Receptor-Associated Factor 6
Glycogen Synthase Kinase 3
2,7-naphthyridinone-based MET kinase inhibitors: A promising novel scaffold for antitumor drug development
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 178, 页码: 705-714
作者:
Zhuo, Lin-Sheng
;
Xu, Hong-Chuang
;
Wang, Ming-Shu
;
Zhao, Xing-E
;
Ming, Zhi-Hui
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  |  
浏览/下载:4/0
  |  
提交时间:2019/12/23
2,7-Naphthyridone
Antitumor
In vivo efficacy
MET kinase inhibitor
Natural products as important tyrosine kinase inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 182, 页码: 111664
作者:
Yin, Bo
;
Fang, Dong-Mei
;
Zhou, Xian-Li
;
Gao, Feng
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/11/04
Natural products
Tyrosine kinase inhibitors
Bcr-Abl
JAK-STAT
EGFR
VEGFR
IGF-1R
c-Met(HGFR)
PDGFR
FGFR
HER-2/neu
Preclinical Evaluation of SCC244 (Glumetinib), a Novel, Potent, and Highly Selective Inhibitor of c-Met in MET-dependent Cancer Models
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2018, 卷号: 17, 期号: 4, 页码: 751-762
作者:
Ai, Jing
;
Chen, Yi
;
Peng, Xia
;
Ji, Yinchun
;
Xi, Yong
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/01/08
Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Jiang, Alan
;
Liu, Qiufeng
;
Wang, Ruifeng
;
Wei, Peng
;
Dai, Yang
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  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
cancer
FGFR
kinase inhibitor
pyrrolo[2,3-b]pyrazine
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