Natural products as important tyrosine kinase inhibitors

doi:10.1016/j.ejmech.2019.111664

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	Natural products as important tyrosine kinase inhibitors
	Yin, Bo 2; Fang, Dong-Mei 1; Zhou, Xian-Li 2; Gao, Feng 2
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2019
卷号	182 页码:111664
关键词	Natural products Tyrosine kinase inhibitors Bcr-Abl JAK-STAT EGFR VEGFR IGF-1R c-Met(HGFR) PDGFR FGFR HER-2/neu
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2019.111664
产权排序	2
文献子类	Review
英文摘要	As an important source of drugs, natural products play an important role in the discovery and development of new drugs. More than 60% of anti-tumor drugs are closely related to natural products. At the same time, as the main cause of tumors, the abnormal activity of tyrosine kinase has become an important target for clinical treatment. Although, small molecule targeted drugs dominate the cancer treatment. Natural active products are driving the development of new tyrosine kinase inhibitors with their unique mode of action and molecular structure diversity. Obtaining new chemical entities with tyrosine kinase inhibitory activity from natural active products will bring new breakthroughs in the research of anticancer drugs. In this paper, different tyrosine kinases are mainly classified as targets, and natural products and derivatives which have been found to inhibit tyrosine kinase activity have been described. It is hoped that by analyzing the different aspects of the source, structural characteristics, mechanism of action and biological activity of these natural products, we will find new members that can be developed into drugs and promote the development of anti-tumor drugs. (C) 2019 Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry & Analysis
URL标识	查看原文
WOS关键词	GROWTH-FACTOR RECEPTOR ; FACTOR-I RECEPTOR ; ANTI-ANGIOGENIC ACTIVITY ; BIOLOGICAL EVALUATION ; CELL-MIGRATION ; ANTITUMOR ACTIVITIES ; SIGNALING PATHWAYS ; CANCER-CELLS ; LUNG-CANCER ; PROLIFERATION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000496896600010
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30978]
专题	公共实验与分析中心
通讯作者	Gao, Feng
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China 2.Southwest Jiaotong Univ, Sch Life Sci & Engn, Lab Chem & Biodivers, Chengdu 610031, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Yin, Bo,Fang, Dong-Mei,Zhou, Xian-Li,et al. Natural products as important tyrosine kinase inhibitors[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2019,182:111664.
APA	Yin, Bo,Fang, Dong-Mei,Zhou, Xian-Li,&Gao, Feng.(2019).Natural products as important tyrosine kinase inhibitors.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,182,111664.
MLA	Yin, Bo,et al."Natural products as important tyrosine kinase inhibitors".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 182(2019):111664.