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上海药物研究所 [19]
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期刊论文 [37]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
P300/CBP inhibition sensitizes mantle cell lymphoma to PI3K delta inhibitor idelalisib
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhou, Xiao-ru
;
Li, Xiao
;
Liao, Li-ping
;
Han, Jie
;
Huang, Jing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/06/11
mantle cell lymphoma
idelalisib
drug resistance
P300
CBP
synergistic drug action
PI3Kδ
epigenetics
Synthesis and evaluation of new thiourea derivatives as antitumor and antiangiogenic agents
期刊论文
TETRAHEDRON LETTERS, 2020, 卷号: 61, 期号: 40
作者:
Bai, Wenjing
;
Ji, Jianxin
;
Huang, Qiang
;
Wei, Wei
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/11/25
Thiourea derivatives
Antitumor
Antiangiogenesis
RTK inhibitors
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
Discovery of novel anti-angiogenesis agents. Part 9: Multiplex inhibitors suppressing compensatory activations of RTKs.
期刊论文
European journal of medicinal chemistry, 2019, 卷号: 164, 页码: 440-447
作者:
Shan Yuanyuan
;
Si Ru
;
Wang Jin
;
Zhang Qingqing
;
Zhou Huaxin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/11/19
Anti-angiogenic agents
1,2,3-Triazole
RTK inhibitors
Multi-target
Compensatory activation
Survivin-targeting miR-542-3p overcomes HER3 signaling-induced chemoresistance and enhances the antitumor activity of paclitaxel against HER2-overexpressing breast cancer
期刊论文
Cancer Letters, 2018, 卷号: 420, 页码: 97-108
作者:
Lyu, Hui
;
Wang, Shuiliang
;
Huang, Jingcao
;
Wang, Bolun
;
He, Zhimin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/03
HER3
Survivin
miRNA
Paclitaxel resistance
Breast cancer
RTKs
Receptor tyrosine kinases
PI-3K
Phosphoinositide 3-kinase
CHX
Cycloheximide
ELISA
Enzyme-linked immunosorbent assay
IHC
Immunohistochemistry
i.p.
Intraperitoneal
New strategies in achieving antiangiogenic effect: Multiplex inhibitors suppressing compensatory activations of RTKs
期刊论文
MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 页码: 1674-1705
作者:
Shan, Yuanyuan
;
Wang, Binghe
;
Zhang, Jie
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/11/26
vascular normalization
antiangiogenic effect
multiplex inhibitors
receptor tyrosine kinase
compensatory activation
Phase I safety and pharmacokinetic study of cipatinib, an original dual tyrosine kinase inhibitor
期刊论文
2018, 卷号: 9, 期号: 8, 页码: 1041-1047
作者:
Wang, Jiayu
;
Han, Yiqun
;
Shi, Xiuqing
;
Li, Qing
;
Zhang, Pin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/03
Advanced breast cancer
cipatinib
HER2
phase I trial
RTKs
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