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上海药物研究所 [54]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
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浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13
作者:
Hua, Chen
;
Shena, Lijuan
;
Zoua, Fengming
;
Wua, Yun
;
Wanga, Beilei
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  |  
浏览/下载:7/0
  |  
提交时间:2023/11/10
Acquired resistance mutations
CDK9 inhibitors
Transcription
Single nucleotide polymorphisms
BAY1251152
Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2022
作者:
Wang, Zuo-wei
;
Zou, Feng-ming
;
Wang, Ao-li
;
Yang, Jing
;
Jin, Rui
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  |  
浏览/下载:17/0
  |  
提交时间:2022/12/22
AZD4547
RIPK1
inhibitors
SIRS model
anti-necroptosis
Protein degradation technology: a strategic paradigm shift in drug discovery
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:
Li, Haobin
;
Dong, Jinyun
;
Cai, Maohua
;
Xu, Zhiyuan
;
Cheng, Xiang-Dong
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  |  
浏览/下载:30/0
  |  
提交时间:2021/11/01
Protein degradation
Degradation pathway
Degradation technology
PROTAC
Monomeric degraders
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
Novel Carborane Compounds Based on Cyclooxygenase-2 Inhibitors for Effective Boron Neutron Capture Therapy of Tongue Squamous Cell Carcinoma
期刊论文
CHEMISTRYSELECT, 2020, 卷号: 5, 期号: 46, 页码: 14652-14660
作者:
Zhang, Taofeng
;
Du, Shaobo
;
Wang, Yu
;
Guo, Yanzhu
;
Yi, Yangman
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  |  
浏览/下载:47/0
  |  
提交时间:2021/12/13
Boron neutron capture therapy
Tongue squamous cell carcinoma
COX-2 inhibitors
Biological activity
Growth factors
Repurposing of Kinase Inhibitors for Treatment of COVID-19
期刊论文
PHARMACEUTICAL RESEARCH, 2020, 卷号: 37
作者:
Weisberg, Ellen
;
Parent, Alexander
;
Yang, Priscilla L.
;
Sattler, Martin
;
Liu, Qingsong
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  |  
浏览/下载:31/0
  |  
提交时间:2020/10/26
Coronavirus
SARS-CoV-2
SARS-CoV
MERS-CoV
kinase inhibitors
pharmacokinetics
antiviral therapy
COVID-19
Uncommon nornardosinane, seconeolemnane and related sesquiterpenoids from Xisha soft coral Litophyton nigrum
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 96, 页码: 8
作者:
Yang, Fan
;
Li, Song-Wei
;
Zhang, Jun
;
Liang, Lin-Fu
;
Lu, Yan-Hua
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Litophyton nigrum
Nornardosinane
Seconeolemnane
Cytotoxicity
Inhibitory activity
Isothermal kinase-triggered supramolecular assemblies as drug sensitizers
期刊论文
CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 1132-1139
作者:
Liu, Dongdong
;
Miao, Zhe
;
Wu, Chengling
;
He, Fangfei
;
Ren, Peng
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/03/24
PD-L1 expression levels on tumor cells affect their immunosuppressive activity
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407
作者:
Zheng, Yang
;
Fang, You-Chen
;
Li, Jing
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  |  
浏览/下载:53/0
  |  
提交时间:2020/07/01
programmed cell death 1
programmed death-ligand 1
co-culture
immunosuppression
signaling pathway
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