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上海药物研究所 [33]
暨南大学 [15]
厦门大学 [13]
复旦大学上海医学院 [10]
山东大学 [7]
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期刊论文 [103]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment
期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:
Zhang, Jinhua
;
Si, Jing
;
Gan, Lu
;
Zhou, Rong
;
Guo, Menghuan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/01/12
DNA damage
DNA repair
particle therapy
photon therapy
radiosensitizer
Design, Synthesis, and Biological Evaluation of HSP90 Inhibitor-SN38 Conjugates for Targeted Drug Accumulation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 10, 页码: 5421-5441
作者:
Zhu, Shulei
;
Shen, Qianqian
;
Gao, Yinglei
;
Wang, Lei
;
Fang, Yanfen
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/12/24
DCZ5248, a novel dual inhibitor of Hsp90 and autophagy, exerts antitumor activity against colon cancer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Chen, Xiang-ling
;
Liu, Peng
;
Zhu, Wei-liang
;
Lou, Li-guang
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  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
DCZ5248
Hsp90
autophagy
lysosomal function
antitumor activity
colon cancer
Optimized HSP90 mediated fluorescent probes for cancer-specific bioimaging
期刊论文
JOURNAL OF MATERIALS CHEMISTRY B, 2020, 卷号: 8, 期号: 9, 页码: 1878-1896
作者:
Zhu, Shulei
;
Li, Yalei
;
Huang, Yushu
;
Zhang, Minmin
;
Gu, Xiaofan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Time course analysis of immunity-related gene expression in the sea cucumber Apostichopus japonicus during exposure to thermal and hypoxic stress
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 95, 页码: 383-390
作者:
Huo, Da
;
Sun, Lina
;
Zhang, Libin
;
Yang, Hongsheng
;
Liu, Shilin
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/03/20
Anoxia
Heat stress
Global climate change
Holothurian
Echinoderm
Immune system
High temperature
Immune-associated genes
Stress response
Aquaculture
Design, Synthesis and Pharmacological Evaluation of Novel Hsp90N-terminal Inhibitors Without Induction of Heat Shock Response
期刊论文
CHEMISTRYOPEN, 2019, 卷号: 8, 期号: 3, 页码: 344-353
作者:
Liu, Peng
;
Chen, Xiangling
;
Zhu, Jianming
;
Li, Bo
;
Chen, Zhaoqiang
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
autophagy
Hsp72
Hsp90 inhibitor
triazines
antitumor activity
Recent Advances in the Discovery of Novel HSP90 Inhibitors: An Update from 2014
期刊论文
Current drug targets, 2019
作者:
Xiao Yan
;
Liu Yajun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/02
HSP90
Anticancer
Drug design
HSP90 inhibitor
HSP90β GRP94
Lead optimization
HSP90 inhibitor DPB induces autophagy and more effectively apoptosis in A549 cells combined with autophagy inhibitors
期刊论文
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2019, 卷号: 55, 期号: 5, 页码: 349-354
作者:
Zhao, YanChun
;
Li, Kunlun
;
Zhao, BaoXiang
;
Su, Le
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/11
HSP90 inhibitor
DPB
A549
Autophagy
Apoptosis
Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma
期刊论文
CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 3, 页码: 352-3650000000
作者:
Liu, Zhenzhen
;
Li, Hongli
;
He, Lian
;
Xiang, Yu
;
Tian, Chengsen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
calcineurin
cancer therapy
cell signaling
click chemistry
drug screening
gene expression
glioblastoma
HSP90 inhibitor
NFAT
proteomics
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