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科研机构
上海药物研究所 [45]
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期刊论文 [45]
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2020 [4]
2019 [7]
2018 [5]
2017 [4]
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Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum
期刊论文
FITOTERAPIA, 2020, 卷号: 146, 页码: 5
作者:
Wang, Qi-Qi
;
Wang, Xiao-Dong
;
Wu, Ling-Zhi
;
Fang, Qiang-Qiang
;
Liu, Ya-Nan
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2020/12/24
Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides
期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 99, 页码: 5
作者:
Wang, Xiao-Feng
;
Zhu, Zhengdan
;
Hao, Ting-Ting
;
Fang, Qiang-Qiang
;
Jiang, Kun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
Sophora alopecuroides
Alkaloids
Cl-containing matrines
Absolute configuration
Immunosuppressive activity
Heterogeneous immunogenomic features and distinct escape mechanisms in multifocal hepatocellular carcinoma
期刊论文
JOURNAL OF HEPATOLOGY, 2020, 卷号: 72, 期号: 5, 页码: 896-908
作者:
Dong, Liang-qing
;
Peng, Li-hua
;
Ma, Li-jie
;
Liu, Dong-bing
;
Zhang, Shu
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2020/07/01
Hepatocellular carcinoma
Tumor heterogeneity
Tumor microenvironment
Immunoediting
Neoantigen
Exploring Conformational Change of Adenylate Kinase by Replica Exchange Molecular Dynamic Simulation
期刊论文
BIOPHYSICAL JOURNAL, 2020, 卷号: 118, 期号: 5, 页码: 1009-1018
作者:
Wang, Jinan
;
Peng, Cheng
;
Yu, Yuqu
;
Chen, Zhaoqiang
;
Xu, Zhijian
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
期刊论文
CELL, 2019, 卷号: 179, 期号: 2, 页码: 561-+
作者:
Gao, Qiang
;
Zhu, Hongwen
;
Dong, Liangqing
;
Shi, Weiwei
;
Chen, Ran
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
The study on size dependent dipole dipole interaction in the self-assembly of twisting nanoribbons with circular polarization activation
期刊论文
NANOTECHNOLOGY, 2019, 卷号: 30, 期号: 38, 页码: 8
作者:
Yan, Bo
;
Ma, Chenghua
;
Lv, Bin
;
Zhu, Junwen
;
Li, Yun
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
circular polarization
CdTe QDs
photooxidation
self-assembly
nanostructures
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
new dinorditerpenoids from Flueggea virosa
期刊论文
FITOTERAPIA, 2019, 卷号: 133, 页码: 96-101
作者:
Wang, Xiao-Feng
;
Liu, Fei-Fei
;
Zhu, Zhengdan
;
Fang, Qiang-Qiang
;
Qu, Shi-Jin
收藏
  |  
浏览/下载:100/0
  |  
提交时间:2019/04/02
Flueggea Virosa
13-methyl-ent-podocarpane
Securinega Alkaloids
Tddft Ecd
Anti-hcv
Flueggenoids A - E, new dinorditerpenoids from Flueggea virosa
期刊论文
FITOTERAPIA, 2019, 卷号: 133, 页码: 96-101
作者:
Wang, Xiao-Feng
;
Liu, Fei-Fei
;
Zhu, Zhengdan
;
Fang, Qiang-Qiang
;
Qu, Shi-Jin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
Flueggea virosa
13-Methyl-ent-podocarpane
Securinega alkaloids
TDDFT ECD
Anti-HCV
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