new dinorditerpenoids from Flueggea virosa | |
Wang, Xiao-Feng3,4; Liu, Fei-Fei2,3; Zhu, Zhengdan1,3; Fang, Qiang-Qiang3,4; Qu, Shi-Jin4; Zhu, Weiliang1; Yang, Li2; Zuo, Jian-Ping2; Tan, Chang-Heng4 | |
刊名 | FITOTERAPIA |
2019-03 | |
卷号 | 133页码:96-101 |
关键词 | Flueggea Virosa 13-methyl-ent-podocarpane Securinega Alkaloids Tddft Ecd Anti-hcv |
ISSN号 | 0367-326X |
DOI | 10.1016/j.fitote.2018.12.025 |
文献子类 | Article |
英文摘要 | A phytochemical investigation on the twigs and leaves of Flueggea virosa (Euphorbiaceae) led to the isolation of flueggenoids A - E (1-5), five new 13-methyl-ent-podocarpanes, together with eleven known compounds (6-16). Their structures and absolute configurations were elucidated on the basis of extensive MS and NMR data analysis, and/or single-crystal X-ray diffraction, time-dependent density functional theory (TDDFT)-based electronic circular dichroism (ECD) calculations, and chemical transformation. All isolates were evaluated for anti-HCV activity, the results showed that terpenoids of F. virosa had nonnegligible contribution for the anti-HCV activity. |
资助项目 | National Science & Technology Major Project Key New Drug Creation and Manufacturing Program ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program ; Ministry of Science and Technology, China |
WOS关键词 | Indolizidine Alkaloids ; Securinega Alkaloids ; Diterpenoids ; Skeleton ; Roots |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE BV |
WOS记录号 | WOS:000461536300016 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/279992] |
专题 | 天然药物化学研究室 |
通讯作者 | Yang, Li; Tan, Chang-Heng |
作者单位 | 1.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Xiao-Feng,Liu, Fei-Fei,Zhu, Zhengdan,et al. new dinorditerpenoids from Flueggea virosa[J]. FITOTERAPIA,2019,133:96-101. |
APA | Wang, Xiao-Feng.,Liu, Fei-Fei.,Zhu, Zhengdan.,Fang, Qiang-Qiang.,Qu, Shi-Jin.,...&Tan, Chang-Heng.(2019).new dinorditerpenoids from Flueggea virosa.FITOTERAPIA,133,96-101. |
MLA | Wang, Xiao-Feng,et al."new dinorditerpenoids from Flueggea virosa".FITOTERAPIA 133(2019):96-101. |
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