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The allosteric gating mechanism of the MthK channel
期刊论文
NATIONAL SCIENCE REVIEW, 2022, 卷号: 9
作者:
Guan, Fenghui
;
Li, Tianyu
;
Dong, Wei
;
Guo, Rui
;
Chai, Hao
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/12/23
ion channel
allosteric gating mechanism
protein structural data analysis
Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 7, 页码: 14
作者:
Zhou, Qingtong
;
Guo, Wanjing
;
Dai, Antao
;
Cai, Xiaoqing
;
Vass, Marton
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2021/08/17
GLP-1R
virtual screening
allosteric modulator
drug discovery
molecular docking
Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins*
期刊论文
CHINESE PHYSICS B, 2021, 卷号: 30, 期号: 3, 页码: 8
作者:
Lu, Shouqin
;
Ding, Qihan
;
Zhang, Mingkun
;
Long, Mian
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2021/04/20
molecular dynamics simulations
mechanosensitive protein
allosteric dynamics
integrin
Multi-scale molecular dynamics simulations and applications on mechanosensitive proteins of integrins*
期刊论文
CHINESE PHYSICS B, 2021, 卷号: 30, 期号: 3, 页码: 8
作者:
Lv SQ(吕守芹)
;
Ding QH(丁奇寒)
;
Zhang MK(张明坤)
;
Long M(龙勉)
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/04/19
molecular dynamics simulations
mechanosensitive protein
allosteric dynamics
integrin
Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020)
期刊论文
CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842
作者:
Wu, Jingwei
;
Zhang, Huan
;
Zhao, Guilong
;
Wang, Runling
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2021/08/17
SHP2 inhibitor
PTPN11 gene
allosteric
cancer
combination therapy
clinical trial
Azorhizobium caulinodans c-di-GMP phosphodiesterase Chp1 involved in motility, EPS production, and nodulation of the host plant
期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 卷号: 104, 期号: 6, 页码: 2715-2729
作者:
Sun, Yu
;
Liu, Yanan
;
Liu, Xiaolin
;
Dang, Xiaoxiao
;
Dong, Xiaoyan
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2020/07/08
CYCLIC DIGUANYLATE
PSEUDOMONAS-AERUGINOSA
SINORHIZOBIUM-MELILOTI
SESBANIA-ROSTRATA
ACETOBACTER-XYLINUM
ALLOSTERIC CONTROL
CRYSTAL-STRUCTURES
BIOFILM FORMATION
VIBRIO-CHOLERAE
PAS DOMAINS
Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Revealing the Positive Binding Cooperativity Mechanism between the Orthosteric and the Allosteric Antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 628-637
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Hongli
;
Zhang, Qianqian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/01/18
CC chemokine receptor 2
orthosteric antagonist
allosteric antagonist
binding cooperativity
metadynamics simulation
Gaussian accelerated MD simulation
recentadvancesindopaminergicstrategiesforthetreatmentofparkinsonsdisease
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 4, 页码: 471
作者:
Mao Qi
;
Qin Wangzhi
;
Zhang Ao
;
Ye Na
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Parkinson’s disease
dopamine
D_1 receptor
D_2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
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