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科研机构
西北高原生物研究所 [18]
上海药物研究所 [17]
复旦大学上海医学院 [6]
中国科学院大学 [3]
厦门大学 [2]
深圳先进技术研究院 [2]
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期刊论文 [54]
会议论文 [2]
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2020 [2]
2018 [5]
2017 [1]
2016 [14]
2015 [12]
2014 [2]
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Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10
作者:
Jiang, Zongru
;
Wang, Li
;
Liu, Xuesong
;
Chen, Cheng
;
Wang, Beilei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Cancer
VEGFR2 kinase
Kinase inhibitor
Angiogenesis
Inhibitor selectivity
Regulation of hypoxia-inducible factor functions in the nucleus by sphingosine-1-phosphate
期刊论文
FASEB JOURNAL, 2020, 页码: 18
作者:
Hait, Nitai C.
;
Maiti, Aparna
;
Xu, Pan
;
Qi, Qianya
;
Kawaguchi, Tsutomu
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
hypoxia-inducible factors
sphingosine-1-phosphate
sphingosine kinase 2
triple-negative breast cancer
PBA2 exhibits potent anti-tumor activity via suppression of VEGFR2 mediated-cell proliferation and angiogenesis
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2018, 卷号: 150, 页码: 131-140
作者:
Fang, Xiaona
;
Xie, Hua
;
Luo, Min
;
Chen, Zhen
;
Wang, Fang
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Angiogenesis
And-tumor activity
Multi-tyrosine kinases inhibitor
PBA2
VEGFR2
Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor
期刊论文
CANCER SCIENCE, 2018, 卷号: 109, 期号: 4, 页码: 1207-1219
作者:
Xie, Chengying
;
Wan, Xiaozhe
;
Quan, Haitian
;
Zheng, Mingyue
;
Fu, Li
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
angiogenesis
anlotinib
tyrosine kinase inhibitor
VEGF
VEGFR2
VEGF-A regulates sFlt-1 production in trophoblasts through both Flt-1 and KDR receptors.
期刊论文
Molecular and Cellular Biochemistry, 2018
作者:
Zhong-Lin Xiao
;
Songjun Li
;
Yan Yu
;
Mengxia Li
;
Jie Chen
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/31
Application of EGFR inhibitor reduces circulating tumor cells during transcatheter arterial embolization
期刊论文
CLINICAL & TRANSLATIONAL ONCOLOGY, 2018, 卷号: 20, 期号: 5
作者:
Zhu, L.
;
Liu, R.
;
Zhang, W.
;
Qian, S.
;
Wang, J.
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Transcatheter arterial embolization (TAE)
Transient hepatic artery ligation (HAL)
Hepatocellular carcinoma (HCC)
Epidermal growth factor receptor (EGFR)
Vascular endothelial growth factor-A (VEGF-A)
Stromal cell-derived factor 1 (SDF-1)
Slug
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma
期刊论文
SCIENTIFIC REPORTS, 2017
Dai, Jie
;
Wu, Shan
;
Kong, Yan
;
Chi, Zhihong
;
Si, Lu
;
Sheng, Xinan
;
Cui, Chuanliang
;
Fang, Jing
;
Zhang, Jue
;
Guo, Jun
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
ANTICANCER AGENTS
SIGNALING PATHWAY
INDUCE APOPTOSIS
CELL CARCINOMA
CANCER-THERAPY
JURKAT CELLS
PHASE-II
CALCIUM
DEATH
TRIAL
Eriocalyxin B, a natural diterpenoid, inhibited VEGF-induced angiogenesis and diminished angiogenesis-dependent breast tumor growth by suppressing VEGFR-2 signaling
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 50, 页码: 82820-82835
作者:
Zhou, Xunian
;
Yue, Grace Gar-Lee
;
Liu, Minghua
;
Zuo, Zhili
;
Lee, Julia Kin-Ming
收藏
  |  
浏览/下载:244/0
  |  
提交时间:2017/02/28
Eriocalyxin B
angiogenesis
vascular endothelial growth factor (VEGF)
vascular endothelial growth factor receptor 2(VEGFR-2)
breast cancer
Discovery of 1,3-Diaryl-pyridones as Potent VEGFR-2 Inhibitors: Design, Synthesis, and Biological Evaluation
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 87, 期号: 5, 页码: 694-703
作者:
Yan, Wei
;
Huang, Zhaoru
;
Wang, Zhengyu
;
Cao, Sufen
;
Tong, Linjiang
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/01/08
1
3-Diaryl-pyridone
angiogenesis
anticancer agent
Chan-Lam coupling
VEGFR-2 inhibitors
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