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科研机构
大连化学物理研究所 [17]
复旦大学上海医学院 [5]
上海药物研究所 [1]
西北高原生物研究所 [1]
生态环境研究中心 [1]
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期刊论文 [20]
会议论文 [5]
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2019 [2]
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2015 [2]
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物理化学 [6]
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Per- and polyfluoroalkyl substances display structure-dependent inhibition towards UDP-glucuronosyltransferases
期刊论文
ENVIRONMENTAL POLLUTION, 2019, 卷号: 254, 页码: -
作者:
Liu, Yong-Zhe
;
Zhang, Zhi-Peng
;
Fu, Zhi-Wei
;
Yang, Kun
;
Ding, Ning
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/09/10
Per- and polyfluoroalkyl substances (PFASs)
UDP-Glucuronosyltransferases (UGTs)
Half inhibition concentration (IC50)
Inhibition type
Inhibition kinetic parameters (Ki)
In vitro-in vivo extrapolation (IVIVE)
Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine
期刊论文
INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY, 2019, 卷号: 21, 期号: 5
作者:
Yang, Hongxia
;
Xiao, Yuancan
;
Li, Cen
;
Gao, Tingting
;
Wei, Lixin
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/11/26
Tibetan traditional medicine
Swertia mussotii
Cytochrome P450
Hepatic transporters
Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury
期刊论文
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE, 2017, 卷号: 25
作者:
Sun, Yirui
;
Yu, Jian
;
Yuan, Qiang
;
Wu, Xing
;
Wu, Xuehai
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Traumatic brain injury
Valproic acid
Seizure
UGT1A6
CYP2C9
Genetic polymorphisms
The Inhibition of UDP-Glucuronosyltransferase (UGT) Isoforms by Praeruptorin A and B
期刊论文
PHYTOTHERAPY RESEARCH, 2016, 卷号: 30, 期号: 11, 页码: 1872-1878
作者:
Zhao, Zhenying
;
Huang, Chun-Ting
;
Du, Zuo
;
Yu, Yang
;
Fang, Zhong-Ze
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2017/10/29
Praeruptorin A
Praeruptorin B
UDP-glucuronosyltransferases (UGTs)
drug-drug interaction (DDI)
Wedelolactone metabolism in rats through regioselective glucuronidation catalyzed by uridine diphosphate-glucuronosyltransferases 1As (UGT1As)
期刊论文
PHYTOMEDICINE, 2016, 卷号: 23, 期号: 4, 页码: 340-349
作者:
Li, Liang
;
Huang, Xue-juan
;
Peng, Jian-long
;
Zheng, Ming-yue
;
Zhong, Da-fang
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Wedelolactone
Metabolism
Uridine diphosphate-glucuronosyltransferase (UGT)
Molecular docking
New insights into the risk of phthalates: Inhibition of UDP-glucuronosyltransferases
期刊论文
CHEMOSPHERE, 2016, 卷号: 144, 页码: 1966-1972
作者:
Liu, Xin
;
Cao, Yun-Feng
;
Ran, Rui-Xue
;
Dong, Pei-Pei
;
Gonzalez, Frank J.
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/06/20
Phthalates
Udp-glucuronosyltransferases (Ugts)
Di-n-octyl Ortho-phthalate (Dnop)
Diphenyl Phthalate (Dphp)
In Vitro Evaluation of the Effect of 7-Methyl Substitution on Glucuronidation of Daphnetin: Metabolic Stability, Isoform Selectivity, and Bioactivity Analysis
期刊论文
journal of pharmaceutical sciences, 2015, 卷号: 104, 期号: 10, 页码: 3557-3564
作者:
Liang, Si-Cheng
;
Ge, Guang-Bo
;
Xia, Yang-Liu
;
Zhang, Jiang-Wei
;
Qi, Xiao-Yi
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2015/11/17
daphnetin
glucuronidation
methyl substitution
structural modification
metabolic stability
phase II enzymes
glucuronosyltransferases
human liver microsomes
enzyme kinetics
metabolic clearance
Structural Modifications at the C-4 Position Strongly Affect the Glucuronidation of 6,7-Dihydroxycoumarins
期刊论文
drug metabolism and disposition, 2015, 卷号: 43, 期号: 4, 页码: 553-560
作者:
Xia, Yang-Liu
;
Ge, Guang-Bo
;
Wang, Ping
;
Liang, Si-Cheng
;
He, Yu-Qi
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/11/17
Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin
期刊论文
drug metabolism and pharmacokinetics, 2014, 卷号: 29, 期号: 2, 页码: 135-140
作者:
Xia, Yang-Liu
;
Liang, Si-Cheng
;
Zhu, Liang-Liang
;
Ge, Guang-Bo
;
He, Gui-Yuan
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2015/11/16
fraxetin
UDP-glucuronosyltransferases (UGTs)
UGT1A9
glucuronidation
human liver microsomes (HLMs)
Comparison of Inhibition Capability of Scutellarein and Scutellarin Towards Important Liver UDP-Glucuronosyltransferase (UGT) Isoforms
期刊论文
phytotherapy research, 2014, 卷号: 28, 期号: 3, 页码: 382-386
作者:
Ma, Guang-You
;
Cao, Yun-Feng
;
Hu, Cui-Min
;
Fang, Zhong-Ze
;
Sun, Xiao-Yu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2015/11/17
enzyme inhibition
UDP-glucuronosyltransferase (UGT)
scutellarin
scutellarein
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