CORC

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CORC

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Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/01
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang
收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01
designsynthesisandbiologicalevaluationofnoveltetrahydroprotoberberinederivativesthpbsasproproteinconvertasesubtilisinkexintype9pcsk9modulatorsforthetreatmentofhyperlipidemia 期刊论文
actapharmaceuticasinicab, 2019, 卷号: 9, 期号: 6, 页码: 1216
作者:  Wu Chenglin;  Xi Cong;  Tong Junhua;  Zhao Jing;  Jiang Hualiang
收藏  |  浏览/下载：52/0  |  提交时间：2020/07/01
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections 期刊论文
ACS INFECTIOUS DISEASES, 2018, 卷号: 4, 期号: 3, 页码: 208-217
作者:  Li, Baoli;  Ni, Shuaishuai;  Chen, Feifei;  Mao, Fei;  Wei, Hanwen
收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08
F463L increases the potential of dofetilide on human ether-a-go-go-related gene (hERG) channels 期刊论文
MICROSCOPY RESEARCH AND TECHNIQUE, 2018, 卷号: 81, 页码: 663-668
作者:  Cheng, Gong;  Wu, Jine;  Han, Wenqi;  Sun, Chaofeng
收藏  |  浏览/下载：3/0  |  提交时间：2019/11/19
An in Vitro Assay of hERG K+ Channel Potency for a New EGFR Inhibitor FHND004 期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:  Jin, Tao;  Hu, Bingxue;  Chen, Shanshan;  Wang, Qiang;  Dong, Xue
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/05
Machine Learning-Based Modeling of Drug Toxicity 期刊论文
Methods in molecular biology (Clifton, N.J.), 2018, 卷号: 1754, 页码: 247-264
作者:  Lu, Jing;  Lu, Dong;  Fu, Zunyun;  Zheng, Mingyue;  Luo, Xiaomin
收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08
Propofol inhibits hERG K+ channels and enhances the inhibition effects on its mutations in HEK293 cells 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 卷号: 791, 页码: 168-178
作者:  Han, Sheng-Na;  Jing, Ying;  Yang, Lin-Lin;  Zhang, Zhao;  Zhang, Li-Rong
收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08
Association of the hERG mutation with long-QT syndrome type 2, syncope and epilepsy 期刊论文
MOLECULAR MEDICINE REPORTS, 2016, 卷号: 13, 期号: [db:dc_citation_issue], 页码: 2467-2475
作者:  Li, Guoliang;  Shi, Rui;  Wu, Jine;  Han, Wenqi;  Zhang, Aifeng
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/02
The mutant L539fs/47 has the effect of an incomplete dominant negative inhibition on wild type HERG current in HEK293 cells 期刊论文
Journal of Xi'an Jiaotong University (Medical Sciences), 2016, 卷号: 37
作者:  Lü, Ying;  Zhang, Jun-Bo;  Zhang, Ai-Feng;  Liu, Zhong-Wei;  Wang, Jun-Kui
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26

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